MAPK11 - mitogen-activated protein kinase 11 Gene

中文名称：丝裂原活化蛋白激酶 11

种属: Homo sapiens

同用名: P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2

基因 ID: 5600 | 基因类型: protein coding

关于 MAPK11

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,263,713-50,270,380 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 19 paralogues. Ubiquitous expression in fat (RPKM 13.9), brain (RPKM 10.1) and 22 other tissues.

功能概要

该基因编码蛋白激酶家族的一个成员，这些蛋白激酶参与多种细胞过程的生化信号整合，包括细胞增殖、分化、转录调节和发育。编码的蛋白质可以被促炎细胞因子和环境压力激活，通过有丝分裂原活化蛋白激酶激酶 (MKK) 的磷酸化。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

MAPK11 基因产物(3)

mRNA	Protein	Name
XM_047441447.1	XP_047297403.1	mitogen-activated protein kinase 11 isoform X1
NR_110887.2
NM_002751.7	NP_002742.3	mitogen-activated protein kinase 11

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MAP kinase activity	IDA IDA: 通过直接分析推断	8663524	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17254968	GOA
enables protein serine/threonine kinase activity	IDA IDA: 通过直接分析推断	35857590	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to UV-B	IDA IDA: 通过直接分析推断	35857590	GOA
involved in cellular response to interleukin-1	IDA IDA: 通过直接分析推断	8663524	GOA
involved in cellular response to virus	IMP IMP: 通过突变表型推断	25754930	GOA
involved in p38MAPK cascade	IDA IDA: 通过直接分析推断	10330143	GOA
NOT involved in positive regulation of erythrocyte differentiation	IMP IMP: 通过突变表型推断	23483889	GOA
involved in positive regulation of gene expression	IMP IMP: 通过突变表型推断	25754930	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: 通过突变表型推断	25754930	GOA
involved in stress-activated MAPK cascade	IDA IDA: 通过直接分析推断	8663524	GOA
involved in stress-activated protein kinase signaling cascade	IDA IDA: 通过直接分析推断	35857590	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAPK11 蛋白结构

Pkinase

0
100
200
300
364 a.a.

蛋白主名

其他名称

mitogen-activated protein kinase 11

MAP kinase 11	MAP kinase p38 beta
mitogen-activated protein kinase p38 beta	mitogen-activated protein kinase p38-2
stress-activated protein kinase-2	stress-activated protein kinase-2b

MAPK11 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
种属内	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
种属内	MAPK11	Q15759	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
种属内	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
种属内	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
种属内	MAPK11	Q15759	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
种属内	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	Y2H	21988832
种属内	MAPK11	Q15759	MAPKAPK3	Homo sapiens	Q16644	TAP	23602568
种属内	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
种属内	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
种属内	MAPK11	Q15759	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
种属内	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Pull Down	17380123
种属内	MAPK11	Q15759	ZNHIT1	Homo sapiens	O43257	Protein Kinase Assay	17380123
种属内	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
种属内	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
种属内	MAPK11	Q15759	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
种属内	MAPK11	Q15759	TP53	Homo sapiens	P04637	Protein Kinase Assay	17254968
种属内	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
种属内	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
种属内	MAPK11	Q15759	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
种属内	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
种属内	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
种属内	MAPK11	Q15759	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Disorder Of Sexual Development

Disorder Of Sex Development	Sex Development Disorder
Sex Differentiation Disease	Dsd
Disorders Of Sex Development	Sex Differentiation Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	纯度	是否罕见病
HY-RS08098	MAPK11 Human Pre-designed siRNA Set A	/	否
HY-RS08099	Mapk11 Mouse Pre-designed siRNA Set A	/	否
HY-RS08100	Mapk11 Rat Pre-designed siRNA Set A	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MAPK11	MGD	MGI:1338024
Felis catus	MAPK11	VGNC	VGNC:68165
Macaca mulatta	MAPK11	VGNC	VGNC:74642
Rattus norvegicus	MAPK11	RGD	RGD:1309340
Bos taurus	MAPK11	VGNC	VGNC:31214
Others	MAPK11	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MAPK11 - mitogen-activated protein kinase 11 Gene

关于 MAPK11

功能概要

MAPK11 基因产物(3)

MAPK11 蛋白结构

MAPK11 蛋白互作信息

关联疾病

直系同源

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MAPK11 - mitogen-activated protein kinase 11 Gene

关于 MAPK11

功能概要

MAPK11 基因产物(3)

MAPK11 蛋白结构

MAPK11 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z