1. Gene
  2. MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

MAP3K9 - mitogen-activated protein kinase kinase kinase 9 Gene

中文名称:丝裂原活化蛋白激酶激酶激酶 9

种属: Homo sapiens

同用名: MLK1; MEKK9; PRKE1

基因 ID: 4293 | 基因类型: protein coding

关于 MAP3K9

Cytogenetic location: 14q24.2 Genomic coordinates (GRCh38): 14:70,722,526-70,809,513 (from NCBI)

This gene has 6 transcripts (splice variants), 194 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.6), testis (RPKM 3.0) and 22 other tissues.

功能概要

启用蛋白质丝氨酸/苏氨酸激酶活性。参与蛋白质自身磷酸化。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022]

MAP3K9 基因产物(4)

mRNA Protein Name
NM_001284230.2 NP_001271159.1 mitogen-activated protein kinase kinase kinase 9 isoform 2
NM_001284231.1 NP_001271160.1 mitogen-activated protein kinase kinase kinase 9 isoform 3
NM_001284232.1 NP_001271161.1 mitogen-activated protein kinase kinase kinase 9 isoform 4
NM_033141.4 NP_149132.2 mitogen-activated protein kinase kinase kinase 9 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function activator activity EXP
EXP: 通过实验结果推断
18714982 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
15610029 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
15610029 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
15610029 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MAP3K9 蛋白结构

SH3_9

SH3_9: Variant SH3 domain (59 - 112)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (144 - 403)

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  • 1000
  • 1104 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 9

mixed lineage kinase 1 (tyr and ser/thr specificity)

MAP3K9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAP3K9 P80192 YWHAG Homo sapiens P61981 32814053
种属内
MAP3K9 P80192 YWHAG Homo sapiens P61981 32814053
种属内
MAP3K9 P80192 YWHAG Homo sapiens P61981 32814053
种属内
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2 32814053
种属内
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2 32814053
种属内
MAP3K9 P80192 SETDB1 Homo sapiens Q15047-2 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retroperitoneal Neuroblastoma
Retroperitoneum Carcinoma

Retroperitoneal Cancer

Malignant Neoplasm Of Retroperitoneum And Peritoneum

Retroperitoneal Neoplasms

Carcinoma Of Retroperitoneum

Carcinoma Of The Retroperitoneum

Malignant Neoplasm Of Retroperitoneum

Malignant Retroperitoneal Cancer

Malignant Tumor Of Peritoneum And Retroperitoneum

Neoplasm Of Retroperitoneum

Neoplasm Of The Retroperitoneum

Retroperitoneal Neoplasm

Tumor Of Retroperitoneum

Malignant Retroperitoneal Tumour

Primary Malignant Neoplasm Of Retroperitoneum

Retroperitoneum Cancer

Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia

Platelet Abnormalities With Eosinophilia And Immune-Mediated Inflammatory Disease

IMD71

Plteid

Immunodeficiency 71

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Ecthyma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MAP3K9 MGD MGI:2449952
Rattus norvegicus MAP3K9 RGD RGD:1562149
Canis familiaris MAP3K9 VGNC VGNC:42980
Bos taurus MAP3K9 VGNC VGNC:31203
Macaca mulatta MAP3K9 VGNC VGNC:74498
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