EIF3E - eukaryotic translation initiation factor 3 subunit E Gene

中文名称：真核翻译起始因子 3 亚基 E

种属: Homo sapiens

同用名: INT6; EIF3S6; EIF3-P48; eIF3-p46

基因 ID: 3646 | 基因类型: protein coding

关于 EIF3E

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:108,201,216-108,248,717 (from NCBI)

This gene has 57 transcripts (splice variants), 234 orthologues and is associated with 57 phenotypes. Ubiquitous expression in ovary (RPKM 226.7), lymph node (RPKM 138.2) and 25 other tissues.

功能概要

启用蛋白质 N 末端结合活性。有助于翻译起始因子活动。参与 mRNA 结合活性的正向调节；基因表达的调节；和翻译启动。位于细胞质和细胞核中。真核翻译起始因子 3 复合体的一部分。与 PML 体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein N-terminus binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; regulation of gene expression; and translational initiation. Located in cytosol and nucleus. Part of eukaryotic translation initiation factor 3 complex. Colocalizes with PML body. [provided by Alliance of Genome Resources, Apr 2022]

EIF3E 基因产物(1)

mRNA	Protein	Name
NM_001568.3	NP_001559.1	eukaryotic translation initiation factor 3 subunit E

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10504338	GOA
contributes to translation initiation factor activity	IDA IDA: 通过直接分析推断	17581632	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: 通过突变表型推断	17468741	GOA
involved in positive regulation of mRNA binding	IPI IPI: 通过物理相互作用推断	24092755	GOA
involved in positive regulation of translation	IPI IPI: 通过物理相互作用推断	24092755	GOA
involved in translational initiation	IDA IDA: 通过直接分析推断	17581632	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with PML body	IDA IDA: 通过直接分析推断	10504338	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10504338	GOA
part of eukaryotic translation initiation factor 3 complex	IDA IDA: 通过直接分析推断	9295280	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: 通过物理相互作用推断	17322308	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10504338	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF3E 蛋白结构

eIF3_N

PCI

0
100
200
300
400
445 a.a.

蛋白主名

其他名称

eukaryotic translation initiation factor 3 subunit E

eIF-3 p48

EIF3E 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Y2H Array	31515488
种属内	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Validated Y2H	25416956
种属内	EIF3E	P60228	C4orf19	Homo sapiens	Q8IY42	Y2H Array	25416956
种属内	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Validated Y2H	32296183
种属内	EIF3E	P60228	ISCA2	Homo sapiens	Q86U28	Y2H Array	32296183
种属内	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Validated Y2H	32296183
种属内	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Y2H Array	32296183
种属内	EIF3E	P60228	KPRP	Homo sapiens	Q5T749	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	32296183
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	32296183
种属内	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Validated Y2H	32296183
种属内	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	ZNF48	Homo sapiens	Q96MX3	Y2H Array	32296183
种属内	EIF3E	P60228	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
种属内	EIF3E	P60228	CD74	Homo sapiens	P04233	Pull Down	30833792
种属内	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Validated Y2H	32296183
种属内	EIF3E	P60228	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
种属内	EIF3E	P60228	DDX60	Homo sapiens	Q8IY21	Pull Down	30833792
种属内	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Y2H Prey Pooling	32296183
种属内	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Validated Y2H	32296183
种属内	EIF3E	P60228	MRNIP	Homo sapiens	Q6NTE8	Y2H Array	32296183
种属内	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Y2H	10504338
种属内	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Pull Down	23623729
种属内	EIF3E	P60228	EIF3C	Homo sapiens	Q99613	Anti Tag CoIP	28514442
种属内	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Bait CoIP	20890303
种属内	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Tag CoIP	33961781
种属内	EIF3E	P60228	EIF3D	Homo sapiens	O15371	Anti Tag CoIP	28514442
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	28514442
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	18599441
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	SLCA	19748344
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Pull Down	23623729
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	SLCA	18599441
种属内	EIF3E	P60228	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	33961781
种属内	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
种属内	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
种属内	EIF3E	P60228	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
种属内	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	33961781
种属内	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	28514442
种属内	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Anti Tag CoIP	35271311
种属内	EIF3E	P60228	EIF3A	Homo sapiens	Q14152	Pull Down	23623729
种属内	EIF3E	P60228	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
种属内	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Pull Down	23623729
种属内	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	SLCA	19748344
种属内	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	SLCA	18599441
种属内	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	33961781
种属内	EIF3E	P60228	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	28514442
种属内	EIF3E	P60228	EPAS1	Homo sapiens	Q99814	Anti Bait CoIP	17324924
种属内	EIF3E	P60228	EPAS1	Homo sapiens	Q99814	Y2H	17324924
种属内	EIF3E	P60228	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
种属间	EIF3E	P60228	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
种属内	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Confocal	10504338
种属内	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Y2H	10504338
种属内	EIF3E	P60228	TRIM27	Homo sapiens	P14373	Anti Tag CoIP	10504338
种属内	EIF3E	P60228	GPBP1L1	Homo sapiens	Q9HC44	Y2H Pooling	16189514
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Y2H Prey Pooling	25416956
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Y2H Pooling	16189514
种属内	EIF3E	P60228	RUNDC3A	Homo sapiens	Q59EK9	Validated Y2H	25416956
种属内	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
种属内	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
种属内	EIF3E	P60228	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

EIF3E 抗体

目录号	产品名	应用	反应物种
HY-P83081	eIF3E Antibody (YA2826)	WB, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04261	EIF3E Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	EIF3E	RGD	RGD:1311521
Felis catus	EIF3E	VGNC	VGNC:81650
Canis familiaris	EIF3E	VGNC	VGNC:40271
Macaca mulatta	EIF3E	VGNC	VGNC:83997
Mus musculus	EIF3E	MGD	MGI:99257
Bos taurus	EIF3E	VGNC	VGNC:28395

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