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  2. EIF3B - eukaryotic translation initiation factor 3 subunit B Gene

EIF3B - eukaryotic translation initiation factor 3 subunit B Gene

中文名称:真核翻译起始因子 3 亚基 B

种属: Homo sapiens

同用名: PRT1; EIF3S9; EIF3-ETA; EIF3-P110; EIF3-P116

基因 ID: 8662 | 基因类型: protein coding

关于 EIF3B

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,354,086-2,380,745 (from NCBI)

This gene has 12 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 39.5), bone marrow (RPKM 32.1) and 25 other tissues.

功能概要

启用 RNA 结合活性。有助于翻译起始因子活动。参与多个过程,包括依赖 IRES 的病毒翻译启动;翻译启动;和病毒翻译终止-重新启动。位于细胞外外泌体。真核翻译起始因子 3 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in several processes, including IRES-dependent viral translational initiation; translational initiation; and viral translational termination-reinitiation. Located in extracellular exosome. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3B 基因产物(5)

mRNA Protein Name
NM_001037283.2 NP_001032360.1 eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362791.2 NP_001349720.1 eukaryotic translation initiation factor 3 subunit B isoform 1
NM_001362792.2 NP_001349721.1 eukaryotic translation initiation factor 3 subunit B isoform 2
NM_001362793.2 NP_001349722.1 eukaryotic translation initiation factor 3 subunit B isoform 2
NM_003751.4 NP_003742.2 eukaryotic translation initiation factor 3 subunit B isoform 1

EIF3B 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (207 - 257)

eIF2A

eIF2A: Eukaryotic translation initiation factor eIF2A (507 - 701)

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  • 814 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 3 subunit B

eukaryotic translation initiation factor 3 subunit 9

EIF3B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF3B P55884 RPS6KB1 Homo sapiens P23443 18423201
种属内
EIF3B P55884 RPS6KB1 Homo sapiens P23443 21986499
种属内
EIF3B P55884 EIF3E Homo sapiens P60228 18599441
种属内
EIF3B P55884 EIF3E Homo sapiens P60228 18599441
种属内
EIF3B P55884 EIF3E Homo sapiens P60228 35271311
种属内
EIF3B P55884 EIF3E Homo sapiens P60228 18628297
种属内
EIF3B P55884 DDX3X Homo sapiens O00571 18628297
种属内
EIF3B P55884 EIF3M Homo sapiens Q7L2H7 18599441
种属内
EIF3B P55884 EIF3M Homo sapiens Q7L2H7 18599441
种属内
EIF3B P55884 EIF3M Homo sapiens Q7L2H7 35271311
种属内
EIF3B P55884 EIF3I Homo sapiens Q13347 14688252
种属内
EIF3B P55884 EIF3I Homo sapiens Q13347 18599441
种属内
EIF3B P55884 EIF3I Homo sapiens Q13347 18628297
种属内
EIF3B P55884 EIF3I Homo sapiens Q13347 35271311
种属内
EIF3B P55884 EIF3K Homo sapiens Q9UBQ5 18599441
种属内
EIF3B P55884 EIF3K Homo sapiens Q9UBQ5 35271311
种属内
EIF3B P55884 EIF3K Homo sapiens Q9UBQ5 18599441
种属内
EIF3B P55884 EIF3K Homo sapiens Q9UBQ5 18628297
种属内
EIF3B P55884 EIF3A Homo sapiens Q14152 19245811
种属内
EIF3B P55884 EIF3A Homo sapiens Q14152 18628297
种属内
EIF3B P55884 EIF3A Homo sapiens Q14152 35271311
种属内
EIF3B P55884 EIF3A Homo sapiens Q14152 14688252
种属内
EIF3B P55884 EIF3G Homo sapiens O75821 18599441
种属内
EIF3B P55884 EIF3G Homo sapiens O75821 35271311
种属内
EIF3B P55884 EIF3G Homo sapiens O75821 14688252
种属内
EIF3B P55884 EIF3G Homo sapiens O75821 30021884
种属内
EIF3B P55884 EIF3G Homo sapiens O75821 18628297
种属内
EIF3B P55884 EIF3J Homo sapiens O75822 14688252
种属内
EIF3B P55884 EIF3J Homo sapiens O75822 18628297
种属内
EIF3B P55884 EIF3J Homo sapiens O75822 35271311
种属内
EIF3B P55884 EIF3L Homo sapiens Q9Y262 18599441
种属内
EIF3B P55884 EIF3L Homo sapiens Q9Y262 18599441
种属内
EIF3B P55884 EIF3L Homo sapiens Q9Y262 35271311
种属内
EIF3B P55884 EIF3H Homo sapiens O15372 18599441
种属内
EIF3B P55884 EIF3H Homo sapiens O15372 18628297
种属内
EIF3B P55884 EIF3H Homo sapiens O15372 35271311
种属内
EIF3B P55884 EIF3H Homo sapiens O15372 18599441
种属内
EIF3B P55884 EIF3F Homo sapiens O00303 18628297
种属内
EIF3B P55884 EIF3F Homo sapiens O00303 35271311
种属内
EIF3B P55884 EIF3F Homo sapiens O00303 18599441
种属内
EIF3B P55884 EIF3F Homo sapiens O00303 18599441
种属内
EIF3B P55884 EIF3F Homo sapiens O00303 19245811
种属内
EIF3B P55884 EIF4G1 Homo sapiens Q04637 23023399
种属内
EIF3B P55884 EIF4G1 Homo sapiens Q04637 35271311
种属间
EIF3B P55884 UL54 Human herpesvirus 1 Q9J0X9 15567442
种属间: 跨种属相互作用 种属内: 同种属相互作用

EIF3B 抗体

目录号 产品名 应用 反应物种
HY-P83000 eIF3B Antibody (YA2745) WB, IHC-P Human

关联疾病

疾病名称 别名
Craniotubular Dysplasia, Ikegawa Type

CTDI

Craniotubular Dysplasia Ikegawa Type

Doid:0112340

Mouth Disease

Mouth Diseases

Mouth Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta EIF3B VGNC VGNC:72193
Bos taurus EIF3B VGNC VGNC:28393
Rattus norvegicus EIF3B RGD RGD:1309018
Canis familiaris EIF3B VGNC VGNC:40269
Felis catus EIF3B VGNC VGNC:61781
Mus musculus EIF3B MGD MGI:106478