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  3. EIF3L - eukaryotic translation initiation factor 3 subunit L Gene

EIF3L - eukaryotic translation initiation factor 3 subunit L Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 3 亚基 L

种属: Homo sapiens

同用名: EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP

基因 ID: 51386 | 基因类型: protein coding

关于 EIF3L

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,849,419-37,889,407 (from NCBI)

This gene has 15 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues.

功能概要

启用 RNA 结合活性。有助于翻译起始因子活动。参与翻译起始和病毒翻译终止-重新起始。位于膜内。真核翻译起始因子 3 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3L 基因产物(3)

mRNA Protein Name
NM_001242923.2 NP_001229852.1 eukaryotic translation initiation factor 3 subunit L isoform 2
NM_001363785.2 NP_001350714.1 eukaryotic translation initiation factor 3 subunit L isoform 3
NM_016091.4 NP_057175.1 eukaryotic translation initiation factor 3 subunit L isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
contributes to translation initiation factor activity IDA
IDA: 通过直接分析推断
17581632 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in translational initiation IDA
IDA: 通过直接分析推断
17581632 GOA
involved in viral translational termination-reinitiation IDA
IDA: 通过直接分析推断
21347434 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of eukaryotic translation initiation factor 3 complex IDA
IDA: 通过直接分析推断
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: 通过物理相互作用推断
17322308 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF3L 蛋白结构

Paf67

Paf67: RNA polymerase I-associated factor PAF67 (151 - 551)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 564 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 3 subunit L

eIEF associated protein HSPC021

EIF3L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF3L Q9Y262 EIF3E Homo sapiens P60228
Pull Down
23623729
种属内
EIF3L Q9Y262 EIF3E Homo sapiens P60228
Anti Tag CoIP
18599441
种属内
EIF3L Q9Y262 EIF3E Homo sapiens P60228
Anti Tag CoIP
33961781
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
28514442
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
18599441
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Y2H Array
32296183
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
SLCA
19748344
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Pull Down
23623729
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Y2H Prey Pooling
25416956
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Anti Tag CoIP
33961781
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Validated Y2H
25416956
种属内
EIF3L Q9Y262 EIF3K Homo sapiens Q9UBQ5
Y2H Prey Pooling
32296183
种属内
EIF3L Q9Y262 EIF3B Homo sapiens P55884
Anti Tag CoIP
33961781
种属间
EIF3L Q9Y262 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma

DMSMFH

Bone Dysplasia With Medullary Fibrosarcoma

Bdmf

Bone Dysplasia With Malignant Fibrous Histiocytoma

Hardcastle Syndrome

Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome

Myopathy, Limb-Girdle, With Bone Fragility

Bone Dysplasia-Medullary Fibrosarcoma Syndrome

Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome

Dms-Mfh

Limb-Girdle Myopathy With Bone Fragility

Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04268 EIF3L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus EIF3L VGNC VGNC:61786
Mus musculus EIF3L MGD MGI:2386251
Rattus norvegicus EIF3L RGD RGD:1308230
Bos taurus EIF3L VGNC VGNC:28402
Canis familiaris EIF3L VGNC VGNC:40278
Macaca mulatta EIF3L VGNC VGNC:84764
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