2. Gene
  3. MRNIP - MRN complex interacting protein Gene

MRNIP - MRN complex interacting protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MRN 复合相互作用蛋白

种属: Homo sapiens

同用名: C5orf45

基因 ID: 51149 | 基因类型: protein coding

关于 MRNIP

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:179,837,276-179,858,817 (from NCBI)

This gene has 24 transcripts (splice variants), 1 gene allele and 122 orthologues. Ubiquitous expression in endometrium (RPKM 41.9), lung (RPKM 28.1) and 25 other tissues.

功能概要

启用染色质结合活性。参与多个过程，包括有丝分裂 G2 DNA 损伤检查点信号；双链断裂修复的调节；和对电离辐射的反应。位于核质中。与 Mre11 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; regulation of double-strand break repair; and response to ionizing radiation. Located in nucleoplasm. Colocalizes with Mre11 complex. [provided by Alliance of Genome Resources, Apr 2022]

MRNIP 基因产物(2)

mRNA Protein Name
NM_001017987.3 NP_001017987.1 MRN complex-interacting protein isoform 2
NM_016175.4 NP_057259.2 MRN complex-interacting protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
27568553 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
27568553 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
27568553 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
27568553 GOA
involved in positive regulation of double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
27568553 GOA
involved in positive regulation of protein kinase activity IMP
IMP: 通过突变表型推断
27568553 GOA
involved in protein localization to chromatin IDA
IDA: 通过直接分析推断
27568553 GOA
involved in regulation of double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
27568553 GOA
involved in response to ionizing radiation IMP
IMP: 通过突变表型推断
27568553 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Mre11 complex IDA
IDA: 通过直接分析推断
27568553 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
27568553 GOA
located in nucleus IDA
IDA: 通过直接分析推断
27568553 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

MRN complex-interacting protein

MRN-interacting protein

MRNIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MRNIP Q6NTE8 NXF1 Homo sapiens Q9UBU9
Validated Y2H
32296183
Intra MRNIP Q6NTE8 DUSP23 Homo sapiens Q9BVJ7
Validated Y2H
32296183
Intra MRNIP Q6NTE8 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra MRNIP Q6NTE8 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Xeroderma Pigmentosum, Complementation Group B

Xeroderma Pigmentosum Group B

Xeroderma Pigmentosum, Group B

XPB

Xpbc

Xp Group B

Xp, Group B

Xeroderma Pigmentosum Complementation Group B

XP-B

Xeroderma Pigmentosum Group B With Cockayne Syndrome

Xeroderma Pigmentosum Ii

Xp2

Xp-B/Cs
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08658 MRNIP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MRNIP VGNC VGNC:52861
Mus musculus MRNIP MGD MGI:1915317
Felis catus MRNIP VGNC VGNC:63584
Canis familiaris MRNIP VGNC VGNC:56068
Macaca mulatta MRNIP VGNC VGNC:84447
Rattus norvegicus MRNIP RGD RGD:1564036
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