EIF3D - eukaryotic translation initiation factor 3 subunit D Gene

中文名称：真核翻译起始因子 3 亚基 D

种属: Homo sapiens

同用名: EIF3S7; eIF3-p66; eIF3-zeta

关于 EIF3D

功能概要

真核翻译起始因子 3 (eIF3) 是最大的 eIF，是由至少十个不同亚基组成的多蛋白复合物。该复合物与 40S 核糖体结合，有助于维持 40S 和 60S 核糖体亚基处于解离状态。它也被认为通过与 eIF2/GTP/甲硫氨酰-tRNA 的三元复合物相互作用并通过促进 mRNA 结合而在 40S 起始复合物的形成中发挥作用。该基因编码的蛋白质是 eIF3 复合体的主要 RNA 结合亚基。[RefSeq 提供，2008 年 7 月]

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]