2. Gene
  3. SAT1 - spermidine/spermine N1-acetyltransferase 1 Gene

SAT1 - spermidine/spermine N1-acetyltransferase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：亚精胺/精胺 N1-乙酰转移酶 1

种属: Homo sapiens

同用名: SAT; DC21; KFSD; SSAT; KFSDX; SSAT-1

基因 ID: 6303 | 基因类型: protein coding

关于 SAT1

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,783,173-23,786,210 (from NCBI)

This gene has 8 transcripts (splice variants), 293 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 336.5), thyroid (RPKM 226.9) and 24 other tissues.

功能概要

该基因编码的蛋白质属于乙酰转移酶家族，是多胺代谢分解代谢途径中的限速酶。它催化亚精胺和精胺的乙酰化，并参与细胞内多胺浓度的调节及其向细胞外的转运。该基因的缺陷与毛囊棘层角化病 (KFSD) 相关。已发现该基因的可变剪接转录本。[RefSeq 提供，2009 年 9 月]

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting Enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

SAT1 基因产物(1)

mRNA Protein Name
NM_002970.4 NP_002961.1 diamine acetyltransferase 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acetyltransferase activity IDA
IDA: 通过直接分析推断
15283699 GOA
enables diamine N-acetyltransferase activity IDA
IDA: 通过直接分析推断
15283699 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiogenesis IEP
IEP: 通过表达模式推断
11866539 GOA
involved in polyamine biosynthetic process IDA
IDA: 通过直接分析推断
15283699 GOA
involved in spermidine acetylation IDA
IDA: 通过直接分析推断
15283699 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SAT1 蛋白结构

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (67 - 145)

  • 0
  • 100
  • 171 a.a.
蛋白主名 其他名称

diamine acetyltransferase 1

diamine N-acetyltransferase 1

SAT1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SAT1 P21673 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
种属内
SAT1 P21673 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
种属内
SAT1 P21673 FH Homo sapiens P07954
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 FH Homo sapiens P07954
Y2H Array
32296183
种属内
SAT1 P21673 CDC42EP1 Homo sapiens Q00587-2
Validated Y2H
32296183
种属内
SAT1 P21673 CDC42EP1 Homo sapiens Q00587-2
Y2H Array
32296183
种属内
SAT1 P21673 CDC42EP1 Homo sapiens Q00587-2
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
种属内
SAT1 P21673 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
种属内
SAT1 P21673 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
种属内
SAT1 P21673 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
种属内
SAT1 P21673 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
种属内
SAT1 P21673 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
种属内
SAT1 P21673 FAM228A Homo sapiens Q86W67
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 FAM228A Homo sapiens Q86W67
Validated Y2H
32296183
种属内
SAT1 P21673 FAM228A Homo sapiens Q86W67
Y2H Array
32296183
种属内
SAT1 P21673 LYRM7 Homo sapiens Q5U5X0
Validated Y2H
32296183
种属内
SAT1 P21673 LYRM7 Homo sapiens Q5U5X0
Y2H Array
32296183
种属内
SAT1 P21673 LYRM7 Homo sapiens Q5U5X0
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
SAT1 P21673 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
SAT1 P21673 BHLHA9 Homo sapiens Q7RTU4
Y2H Array
32296183
种属内
SAT1 P21673 BHLHA9 Homo sapiens Q7RTU4
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 BHLHA9 Homo sapiens Q7RTU4
Validated Y2H
32296183
种属内
SAT1 P21673 SPMIP10 Homo sapiens Q6ZNM6
Validated Y2H
32296183
种属内
SAT1 P21673 SPMIP10 Homo sapiens Q6ZNM6
Y2H Array
32296183
种属内
SAT1 P21673 SPMIP10 Homo sapiens Q6ZNM6
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 CCDC148 Homo sapiens Q8NFR7
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 CCDC148 Homo sapiens Q8NFR7
Y2H Array
19060904
种属内
SAT1 P21673 CCDC148 Homo sapiens Q8NFR7
Y2H Pooling
19060904
种属内
SAT1 P21673 ABHD15 Homo sapiens Q6UXT9
Validated Y2H
32296183
种属内
SAT1 P21673 MYPOP Homo sapiens Q86VE0
Validated Y2H
32296183
种属内
SAT1 P21673 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
种属内
SAT1 P21673 DDX39A Homo sapiens O00148
Validated Y2H
25416956
种属内
SAT1 P21673 DDX39A Homo sapiens O00148
Y2H Array
25416956
种属内
SAT1 P21673 EIF3D Homo sapiens O15371
Validated Y2H
25416956
种属内
SAT1 P21673 MRPL12 Homo sapiens P52815
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 MRPL12 Homo sapiens P52815
Y2H Array
32296183
种属内
SAT1 P21673 MRPL12 Homo sapiens P52815
Validated Y2H
32296183
种属内
SAT1 P21673 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
种属内
SAT1 P21673 PSMA1 Homo sapiens P25786
Y2H Array
32296183
种属内
SAT1 P21673 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 RPP25 Homo sapiens Q9BUL9
Y2H Array
32296183
种属内
SAT1 P21673 RPP25 Homo sapiens Q9BUL9
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 RPP25 Homo sapiens Q9BUL9
Validated Y2H
32296183
种属内
SAT1 P21673 CASP7 Homo sapiens P55210
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 CASP7 Homo sapiens P55210
Validated Y2H
25416956
种属内
SAT1 P21673 CASP7 Homo sapiens P55210
Validated Y2H
32296183
种属内
SAT1 P21673 KCNA4 Homo sapiens P22459
Validated Y2H
32296183
种属内
SAT1 P21673 KCNA4 Homo sapiens P22459
Y2H Pooling
16169070
种属内
SAT1 P21673 KCNA4 Homo sapiens P22459
Y2H Array
32296183
种属内
SAT1 P21673 KCNA4 Homo sapiens P22459
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Y2H Pooling
16189514
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Array
31515488
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Y2H Array
19060904
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Y2H Array
31515488
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Pooling
16189514
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Validated Y2H
25416956
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Validated Y2H
32296183
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Array
25416956
种属内
SAT1 P21673 TCF25 Homo sapiens Q9BQ70
Validated Y2H
32296183
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Array
32296183
种属内
SAT1 P21673 RBM17 Homo sapiens Q96I25
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 MTA1 Homo sapiens Q13330
Validated Y2H
25416956
种属内
SAT1 P21673 MTA1 Homo sapiens Q13330
Y2H Array
25416956
种属内
SAT1 P21673 MTA1 Homo sapiens Q13330
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 COX6C Homo sapiens P09669
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 DIPK1B Homo sapiens Q5VUD6
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 DIPK1B Homo sapiens Q5VUD6
Validated Y2H
25416956
种属内
SAT1 P21673 DIPK1B Homo sapiens Q5VUD6
Validated Y2H
32296183
种属内
SAT1 P21673 DIPK1B Homo sapiens Q5VUD6
Y2H Array
25416956
种属内
SAT1 P21673 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
SAT1 P21673 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
种属内
SAT1 P21673 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
种属内
SAT1 P21673 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
种属内
SAT1 P21673 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
种属内
SAT1 P21673 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
19060904
种属内
SAT1 P21673 NIF3L1 Homo sapiens Q9GZT8
Y2H Pooling
19060904
种属内
SAT1 P21673 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
32296183
种属内
SAT1 P21673 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
32296183
种属内
SAT1 P21673 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属内
SAT1 P21673 C19orf25 Homo sapiens Q9UFG5
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 C19orf25 Homo sapiens Q9UFG5
Y2H Array
25416956
种属内
SAT1 P21673 HOXB9 Homo sapiens P17482
Validated Y2H
25416956
种属内
SAT1 P21673 HOXB9 Homo sapiens P17482
Y2H Array
25416956
种属内
SAT1 P21673 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 TEAD4 Homo sapiens Q15561
Validated Y2H
32296183
种属内
SAT1 P21673 TACO1 Homo sapiens Q9BSH4
Y2H Pooling
16189514
种属内
SAT1 P21673 TACO1 Homo sapiens Q9BSH4
Validated Y2H
32296183
种属内
SAT1 P21673 SAT2 Homo sapiens Q96F10
Y2H Array
31515488
种属内
SAT1 P21673 SAT2 Homo sapiens Q96F10
Y2H Pooling
16189514
种属内
SAT1 P21673 SAT2 Homo sapiens Q96F10
Validated Y2H
32296183
种属内
SAT1 P21673 FAM156B Homo sapiens Q8NDB6
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 FAM156B Homo sapiens Q8NDB6
Validated Y2H
25416956
种属内
SAT1 P21673 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
种属内
SAT1 P21673 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Array
32296183
种属内
SAT1 P21673 KHDC4 Homo sapiens Q7Z7F0-4
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 KHDC4 Homo sapiens Q7Z7F0-4
Validated Y2H
32296183
种属内
SAT1 P21673 DMRT3 Homo sapiens Q9NQL9
Y2H Prey Pooling
32296183
种属内
SAT1 P21673 DMRT3 Homo sapiens Q9NQL9
Validated Y2H
32296183
种属内
SAT1 P21673 DMRT3 Homo sapiens Q9NQL9
Y2H Array
32296183
种属内
SAT1 P21673 DMRT3 Homo sapiens Q9NQL9
Y2H Prey Pooling
25416956
种属内
SAT1 P21673 SNAI2 Homo sapiens O43623
Y2H Array
25416956
种属内
SAT1 P21673 SNAI2 Homo sapiens O43623
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Keratosis Follicularis Spinulosa Decalvans

Kfsd

Keratosis Follicularis Spinulosa Decalvans Cum Ophiasi

Keratosis Follicularis Spinulosa Decalvans, X-Linked

Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Keratosis

Actinic Keratosis

Hyperkeratosis
Tungiasis

Tunga Penetrans Infestation

Chigger Flea

S Penetrans

Sarcopsylla Penetrans

T Penetrans

Tunga Penetrans

Sand-Flea Infestation

Jiggers Infestation

Chigoe Infestation

Jigger Disease
Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome

Mental Retardation, X-Linked, Snyder-Robinson Type

Spermine Synthase Deficiency

Srs

Snyder-Robinson Mental Retardation Syndrome

X-Linked Intellectual Disability Snyder-Robinson Type

Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

Snyder-Robinson X-Linked Mental Retardation Syndrome
Keratosis Pilaris Atrophicans

KPA

Burnett Schwartz Berberian Syndrome
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Olmsted Syndrome, X-Linked

OLMSX

Palmoplantar Keratoderma, Mutilating, With Periorificial Keratotic Plaques, X-Linked

Ppkmx

X-Linked Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

X-Linked Olmsted Syndrome

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques, X-Linked
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12455 SAT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N4161 Euparin Inhibitor ≥99.0% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SAT1 RGD RGD:1586174
Mus musculus SAT1 MGD MGI:98233
Macaca mulatta SAT1 VGNC VGNC:76973
Bos taurus SAT1 VGNC VGNC:34296
Canis familiaris SAT1 VGNC VGNC:82297
Others SAT1 NCBI
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