RPP25 - ribonuclease P and MRP subunit p25 Gene

中文名称：核糖核酸酶 P 和 MRP 亚基 p25

种属: Homo sapiens

基因 ID: 54913 | 基因类型: protein coding

关于 RPP25

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:74,954,418-74,956,772 (from NCBI)

This gene has 1 transcript (splice variant), 240 orthologues and 1 paralogue.

功能概要

启用核糖核酸酶 P RNA 结合活性。有助于核糖核酸酶 P 活性。参与 tRNA 5'-前导去除。位于中心粒卫星和核质中。多聚核糖核酸酶 P 复合物和核糖核酸酶 MRP 复合物的一部分。自闭症的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]

RPP25 基因产物(1)

mRNA	Protein	Name
NM_017793.3	NP_060263.2	ribonuclease P protein subunit p25

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: 通过直接分析推断	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: 通过直接分析推断	30454648	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in tRNA 5'-leader removal	IDA IDA: 通过直接分析推断	16723659	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of multimeric ribonuclease P complex	IDA IDA: 通过直接分析推断	16723659	GOA
part of ribonuclease MRP complex	IDA IDA: 通过直接分析推断	16723659	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPP25 蛋白结构

Alba

0
100
199 a.a.

蛋白主名

其他名称

ribonuclease P protein subunit p25

RNase P protein subunit p25

RPP25 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPP25	Q9BUL9	DNAJB6	Homo sapiens	O75190	Y2H Array	32814053
种属内	RPP25	Q9BUL9	DNAJB6	Homo sapiens	O75190	Validated Y2H	32814053
种属内	RPP25	Q9BUL9	DNAJB6	Homo sapiens	O75190	Y2H Pooling	32814053
种属内	RPP25	Q9BUL9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
种属内	RPP25	Q9BUL9	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
种属内	RPP25	Q9BUL9	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
种属内	RPP25	Q9BUL9	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
种属内	RPP25	Q9BUL9	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
种属内	RPP25	Q9BUL9	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
种属内	RPP25	Q9BUL9	ZNF438	Homo sapiens	Q7Z4V0	Y2H Array	32296183
种属内	RPP25	Q9BUL9	ZNF438	Homo sapiens	Q7Z4V0	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	LRRC73	Homo sapiens	Q5JTD7	Y2H Array	32296183
种属内	RPP25	Q9BUL9	LRRC73	Homo sapiens	Q5JTD7	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
种属内	RPP25	Q9BUL9	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
种属内	RPP25	Q9BUL9	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
种属内	RPP25	Q9BUL9	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	SF3B4	Homo sapiens	Q15427	Y2H Array	32296183
种属内	RPP25	Q9BUL9	SF3B4	Homo sapiens	Q15427	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	PDLIM7	Homo sapiens	Q9NR12	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	PDLIM7	Homo sapiens	Q9NR12	Validated Y2H	32296183
种属内	RPP25	Q9BUL9	PDLIM7	Homo sapiens	Q9NR12	Y2H Array	32296183
种属内	RPP25	Q9BUL9	POP4	Homo sapiens	O95707	Pull Down	15096576
种属内	RPP25	Q9BUL9	POP5	Homo sapiens	Q969H6	Pull Down	15096576
种属内	RPP25	Q9BUL9	POP5	Homo sapiens	Q969H6	Anti Tag CoIP	28514442
种属内	RPP25	Q9BUL9	POP5	Homo sapiens	Q969H6	Anti Tag CoIP	33961781
种属内	RPP25	Q9BUL9	RPP14	Homo sapiens	O95059	Pull Down	15096576
种属内	RPP25	Q9BUL9	RPP14	Homo sapiens	O95059	Anti Tag CoIP	33961781
种属内	RPP25	Q9BUL9	RPP14	Homo sapiens	O95059	Anti Tag CoIP	28514442
种属内	RPP25	Q9BUL9	POP7	Homo sapiens	O75817	Anti Tag CoIP	28514442
种属内	RPP25	Q9BUL9	POP7	Homo sapiens	O75817	Pull Down	15096576
种属内	RPP25	Q9BUL9	POP7	Homo sapiens	O75817	Anti Tag CoIP	33961781
种属内	RPP25	Q9BUL9	POP1	Homo sapiens	Q99575	Anti Tag CoIP	33961781
种属内	RPP25	Q9BUL9	POP1	Homo sapiens	Q99575	Anti Tag CoIP	28514442
种属内	RPP25	Q9BUL9	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	SAT1	Homo sapiens	P21673	Y2H Array	32296183
种属内	RPP25	Q9BUL9	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	KRT15	Homo sapiens	P19012	Y2H Array	32296183
种属内	RPP25	Q9BUL9	RBPMS	Homo sapiens	Q93062-3	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	RBPMS	Homo sapiens	Q93062-3	Y2H Array	32296183
种属内	RPP25	Q9BUL9	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
种属内	RPP25	Q9BUL9	DDI1	Homo sapiens	Q8WTU0	Y2H Array	32296183
种属内	RPP25	Q9BUL9	DDI1	Homo sapiens	Q8WTU0	Y2H Prey Pooling	32296183
种属内	RPP25	Q9BUL9	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
种属内	RPP25	Q9BUL9	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
种属内	RPP25	Q9BUL9	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
种属内	RPP25	Q9BUL9	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
种属内	RPP25	Q9BUL9	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
种属内	RPP25	Q9BUL9	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	RPP25	Q9BUL9	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
种属内	RPP25	Q9BUL9	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Anauxetic Dysplasia 2

ANXD2

Chromosome 15q24 Deletion Syndrome

15q24 Microdeletion Syndrome	Del(15)(Q24)
Monosomy 15q24	15q24 Microdeletion
15q24 Deletion	Interstitial Deletion Of Chromosome 15q24

Diffuse Scleroderma

Diffuse Systemic Sclerosis	Systemic Sclerosis, Diffuse
Scleroderma, Diffuse	Systemic Scleroderma
Progressive System Sclerosis

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12214	RPP25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	RPP25	RGD	RGD:1305290
Bos taurus	RPP25	VGNC	VGNC:34121
Macaca mulatta	RPP25	VGNC	VGNC:77132
Mus musculus	RPP25	MGD	MGI:2143151
Felis catus	RPP25	VGNC	VGNC:64743

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