2. Gene
  3. RPP14 - ribonuclease P/MRP subunit p14 Gene

RPP14 - ribonuclease P/MRP subunit p14 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖核酸酶 P/MRP 亚基 p14

种属: Homo sapiens

同用名: P14

基因 ID: 11102 | 基因类型: protein coding

关于 RPP14

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,306,245-58,320,193 (from NCBI)

This gene has 6 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.8) and 25 other tissues.

功能概要

该基因编码核糖核酸酶 P 的一个亚基，具有 3' 至 5' 核糖核酸外切酶活性。该基因的转录本是双顺反子的，包括 2 型羟酰基硫酯脱水酶 (HTD2) 基因的保守下游开放阅读框。[RefSeq 提供，2017 年 5 月]

This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

RPP14 基因产物(2)

mRNA Protein Name
NM_001098783.3 NP_001092253.1 ribonuclease P protein subunit p14
NM_007042.6 NP_008973.1 ribonuclease P protein subunit p14
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: 通过直接分析推断
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: 通过直接分析推断
30454648 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in tRNA 5'-leader removal IDA
IDA: 通过直接分析推断
16723659 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of multimeric ribonuclease P complex IDA
IDA: 通过直接分析推断
16723659 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
10444065 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPP14 蛋白结构

RNase_P_Rpp14

RNase_P_Rpp14: Rpp14/Pop5 family (23 - 109)

  • 0
  • 100
  • 124 a.a.
蛋白主名 其他名称

ribonuclease P protein subunit p14

ribonuclease P/MRP 14kDa subunit

RPP14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPP14 O95059 ZNF277 Homo sapiens G5E9M4
Y2H Prey Pooling
32296183
Intra RPP14 O95059 ZNF277 Homo sapiens G5E9M4
Y2H Array
32296183
Intra RPP14 O95059 POP4 Homo sapiens O95707
Anti Tag CoIP
33961781
Intra RPP14 O95059 POP4 Homo sapiens O95707
Pull Down
15096576
Intra RPP14 O95059 RPP40 Homo sapiens O75818
Anti Tag CoIP
33961781
Intra RPP14 O95059 POP5 Homo sapiens Q969H6
Pull Down
15096576
Intra RPP14 O95059 POP5 Homo sapiens Q969H6
Anti Tag CoIP
33961781
Intra RPP14 O95059 RPP30 Homo sapiens P78346
Validated Y2H
32296183
Intra RPP14 O95059 RPP30 Homo sapiens P78346
Y2H Array
32296183
Intra RPP14 O95059 RPP30 Homo sapiens P78346
Anti Tag CoIP
33961781
Intra RPP14 O95059 RPP30 Homo sapiens P78346
Y2H Prey Pooling
32296183
Intra RPP14 O95059 RPP25 Homo sapiens Q9BUL9
Anti Tag CoIP
33961781
Intra RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra RPP14 O95059 ACTN2 Homo sapiens P35609
Validated Y2H
32296183
Intra RPP14 O95059 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
32296183
Intra RPP14 O95059 ACTN2 Homo sapiens P35609
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anauxetic Dysplasia 1

Anauxetic Dysplasia

Spondylometaepiphyseal Dysplasia, Menger Type

Spondylometaepiphyseal Dysplasia, Anauxetic Type

Spondyloepimetaphyseal Dysplasia, Anauxetic Type

ANXD1

Anxd

Spondylometaepiphyseal Dysplasia Anauxetic Type

Spondylometaepiphyseal Dysplasia Menger Type

Ad

Spondyloepimetaphyseal Dysplasia, Menger Type

Dysplasia, Anauxetic, Type 1
Chromosome 16p11.2 Deletion Syndrome

Distal 16p11.2 Microdeletion Syndrome

16p11.2 Deletion Syndrome

Del(16)(P11.2)

Microdeletion 16p11.2

Monosomy 16p11.2

Autism, Susceptibility To, 14a

Auts14a

Distal Del(16)(P11.2)

Distal Monosomy 16p11.2
Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type

CHH

Mckusick Type Metaphyseal Chondrodysplasia

Metaphyseal Dysplasia Without Hypotrichosis

Cartilage Hair Hypoplasia Like Syndrome

Metaphyseal Chondrodysplasia Mckusick Type

Chhv

Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

Cartilage-Hair Syndrome

Mckusick'S Metaphyseal Chondrodysplasia Syndrome

Metaphyseal Chondrodysplasia, Recessive Type

Autosomal Recessive Metaphyseal Chondrodysplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12212 RPP14 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPP14 RGD RGD:1305436
Canis familiaris RPP14 VGNC VGNC:108255
Mus musculus RPP14 MGD MGI:1914303
Bos taurus RPP14 VGNC VGNC:109387
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