POP5 - POP5 homolog, ribonuclease P/MRP subunit Gene

中文名称：POP5 同系物，核糖核酸酶 P/MRP 亚基

种属: Homo sapiens

同用名: RPP2; RPP20; hPop5; HSPC004

基因 ID: 51367 | 基因类型: protein coding

关于 POP5

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,578,764-120,581,402 (from NCBI)

This gene has 9 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in adrenal (RPKM 15.3), fat (RPKM 13.2) and 25 other tissues.

功能概要

启用核糖核酸酶 P RNA 结合活性。有助于核糖核酸酶 P 活性。参与 tRNA 5'-前导去除。位于核仁。多聚核糖核酸酶 P 复合物和核糖核酸酶 MRP 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in nucleolus. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

POP5 基因产物(2)

mRNA	Protein	Name
NM_015918.4	NP_057002.2	ribonuclease P/MRP protein subunit POP5 isoform a
NM_198202.2	NP_937845.1	ribonuclease P/MRP protein subunit POP5 isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: 通过直接分析推断	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: 通过直接分析推断	30454648	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in tRNA 5'-leader removal	IDA IDA: 通过直接分析推断	16723659	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of multimeric ribonuclease P complex	IDA IDA: 通过直接分析推断	16723659	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	11413139	GOA
part of ribonuclease MRP complex	IDA IDA: 通过直接分析推断	16723659	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POP5 蛋白结构

RNase_P_Rpp14

0
100
163 a.a.

蛋白主名

其他名称

ribonuclease P/MRP protein subunit POP5

processing of precursor 5, ribonuclease P/MRP subunit

POP5 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	POP5	Q969H6	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	POP5	Q969H6	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	POP5	Q969H6	CCDC102B	Homo sapiens	Q68D86	Y2H Array	32296183
Intra	POP5	Q969H6	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	POP5	Q969H6	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	POP5	Q969H6	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	POP5	Q969H6	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	POP5	Q969H6	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	POP5	Q969H6	CAMK2B	Homo sapiens	Q13554	Validated Y2H	25416956
Intra	POP5	Q969H6	CAMK2B	Homo sapiens	Q13554	Y2H Array	25416956
Intra	POP5	Q969H6	NDUFAB1	Homo sapiens	O14561	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	NDUFAB1	Homo sapiens	O14561	Y2H Array	32296183
Intra	POP5	Q969H6	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	POP5	Q969H6	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	POP5	Q969H6	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	POP5	Q969H6	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	POP4	Homo sapiens	O95707	Anti Tag CoIP	33961781
Intra	POP5	Q969H6	POP4	Homo sapiens	O95707	Pull Down	15096576
Intra	POP5	Q969H6	RPP30	Homo sapiens	P78346	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	RPP30	Homo sapiens	P78346	Anti Tag CoIP	33961781
Intra	POP5	Q969H6	RPP30	Homo sapiens	P78346	Y2H Array	32296183
Intra	POP5	Q969H6	RPP25	Homo sapiens	Q9BUL9	Anti Tag CoIP	33961781
Intra	POP5	Q969H6	POP1	Homo sapiens	Q99575	Anti Tag CoIP	33961781
Intra	POP5	Q969H6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	POP5	Q969H6	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	POP5	Q969H6	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	25416956
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Y2H Array	25416956
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	25416956
Intra	POP5	Q969H6	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Cross	POP5	Q969H6	tax	Human T-cell leukemia virus 1	P14079	Y2H Pooling	22458338

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Anauxetic Dysplasia 2

ANXD2

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Enterocele

Vaginal Enterocele	Hernia
Hernias

Prolapse Of Female Genital Organ

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Anismus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10877	POP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	POP5	MGD	MGI:2151221
Felis catus	POP5	VGNC	VGNC:107718
Bos taurus	POP5	VGNC	VGNC:33165
Canis familiaris	POP5	VGNC	VGNC:44817
Rattus norvegicus	POP5	RGD	RGD:1311819

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POP5 - POP5 homolog, ribonuclease P/MRP subunit Gene

关于 POP5

功能概要

POP5 基因产物(2)

POP5 蛋白结构

POP5 蛋白互作信息

关联疾病

直系同源

热门区域

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POP5 - POP5 homolog, ribonuclease P/MRP subunit Gene

关于 POP5

功能概要

POP5 基因产物(2)

POP5 蛋白结构

POP5 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z