1. Gene
  2. RPP30 - ribonuclease P/MRP subunit p30 Gene

RPP30 - ribonuclease P/MRP subunit p30 Gene

中文名称:核糖核酸酶 P/MRP 亚基 p30

种属: Homo sapiens

同用名: TSG15

基因 ID: 10556 | 基因类型: protein coding

关于 RPP30

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:90,871,974-90,908,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 216 orthologues. Ubiquitous expression in testis (RPKM 4.1), lymph node (RPKM 2.7) and 25 other tissues.

功能概要

启用核糖核酸酶 P RNA 结合活性。有助于核糖核酸酶 P 活性。参与 tRNA 5'-前导去除。多聚核糖核酸酶 P 复合物和核糖核酸酶 MRP 复合物的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Apr 2022]

RPP30 基因产物(2)

mRNA Protein Name
NM_001104546.2 NP_001098016.1 ribonuclease P protein subunit p30 isoform a
NM_006413.5 NP_006404.1 ribonuclease P protein subunit p30 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: 通过直接分析推断
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: 通过直接分析推断
30454648 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in tRNA 5'-leader removal IDA
IDA: 通过直接分析推断
16723659 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of multimeric ribonuclease P complex IDA
IDA: 通过直接分析推断
16723659 GOA
part of ribonuclease MRP complex IDA
IDA: 通过直接分析推断
16723659 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPP30 蛋白结构

RNase_P_p30

RNase_P_p30: RNase P subunit p30 (74 - 224)

  • 0
  • 100
  • 200
  • 268 a.a.
蛋白主名 其他名称

ribonuclease P protein subunit p30

RNase P subunit 2

RPP30 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPP30 P78346 POP5 Homo sapiens Q969H6
Y2H Array
32296183
Intra RPP30 P78346 POP5 Homo sapiens Q969H6
Validated Y2H
32296183
Intra RPP30 P78346 POP5 Homo sapiens Q969H6
Anti Tag CoIP
28514442
Intra RPP30 P78346 POP5 Homo sapiens Q969H6
Y2H Prey Pooling
32296183
Intra RPP30 P78346 RPP14 Homo sapiens O95059
Anti Tag CoIP
28514442
Intra RPP30 P78346 RPP14 Homo sapiens O95059
Anti Tag CoIP
35271311
Intra RPP30 P78346 RPP14 Homo sapiens O95059
Pull Down
15096576
Intra RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Array
25416956
Intra RPP30 P78346 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra RPP30 P78346 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

22q11.2 Distal Deletion Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2, Distal

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPP30 VGNC VGNC:34123
Canis familiaris RPP30 VGNC VGNC:45723
Rattus norvegicus RPP30 RGD RGD:1595116
Felis catus RPP30 VGNC VGNC:64745
Mus musculus RPP30 MGD MGI:1859683
Macaca mulatta RPP30 VGNC VGNC:77040