2. Gene
  3. COX6C - cytochrome c oxidase subunit 6C Gene

COX6C - cytochrome c oxidase subunit 6C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞色素 c 氧化酶亚基 6C

种属: Homo sapiens

基因 ID: 1345 | 基因类型: protein coding

关于 COX6C

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:99,877,865-99,893,707 (from NCBI)

This gene has 11 transcripts (splice variants), 82 orthologues and is associated with 36 phenotypes. Ubiquitous expression in heart (RPKM 104.1), colon (RPKM 92.2) and 25 other tissues.

功能概要

细胞色素 c 氧化酶是线粒体呼吸链的末端酶，催化电子从还原的细胞色素 c 转移到氧气。它是由线粒体基因编码的 3 个催化亚基和核基因编码的多个结构亚基组成的异聚复合物。线粒体编码的亚基在电子传递中起作用，而核编码的亚基可能参与复合物的调控和组装。该核基因编码 VIc 亚基，其与小鼠 VIc 亚基具有 77% 的氨基酸序列同一性。该基因在前列腺癌细胞中上调。在染色体 16p12 上发现了一个假基因。[RefSeq 提供，2010 年 7 月]

Cytochrome c oxidase, the terminal Enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate Cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

COX6C 基因产物(1)

mRNA Protein Name
NM_004374.4 NP_004365.1 cytochrome c oxidase subunit 6C
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17500595 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
30030519 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COX6C 蛋白结构

COX6C

COX6C: Cytochrome c oxidase subunit VIc (3 - 75)

  • 0
  • 75 a.a.
蛋白主名 其他名称

cytochrome c oxidase subunit 6C

cytochrome c oxidase polypeptide VIc

COX6C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
COX6C P09669 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
COX6C P09669 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
COX6C P09669 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
COX6C P09669 SAT1 Homo sapiens P21673
Validated Y2H
32296183
种属内
COX6C P09669 SAT1 Homo sapiens P21673
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

COX6C 抗体

目录号 产品名 应用 反应物种
HY-P82866 Cytochrome C Oxidase subunit Vic Antibody (YA2611) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency

Cox Deficiency

Cytochrome-C Oxidase Deficiency Disease

MC1DN4

Cytochrome-C Oxidase Deficiency

MC4DN1

Mitochondrial Complex I Deficiency, Nuclear Type 4

Complex 4 Mitochondrial Respiratory Chain Deficiency

Complex Iv Deficiency

Mitochondrial Complex 1 Deficiency, Nuclear Type 4

Nuclear Type Mitochondrial Complex I Deficiency 4

Deficiency Of Mitochondrial Respiratory Chain Complex4

MT-C4D

Complex Iv Mitochondrial Respiratory Chain Deficiency

Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03072 COX6C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus COX6C MGD MGI:104614
Rattus norvegicus COX6C RGD RGD:620616
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