2. Gene
  3. CD74 - CD74 molecule Gene

CD74 - CD74 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD74 分子

种属: Homo sapiens

同用名: II; p33; CLIP; DHLAG; HLADG; Ia-GAMMA

基因 ID: 972 | 基因类型: protein coding

关于 CD74

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,401,639-150,412,910 (from NCBI)

This gene has 12 transcripts (splice variants), 207 orthologues and is associated with 57 phenotypes. Broad expression in spleen (RPKM 1835.3), lymph node (RPKM 1421.7) and 24 other tissues.

功能概要

该基因编码的蛋白质与 II 类主要组织相容性复合体 (MHC) 相关，是调节免疫反应抗原呈递的重要伴侣蛋白。它还充当细胞因子巨噬细胞迁移抑制因子 (MIF) 的细胞表面受体，当与编码的蛋白质结合时，它会启动生存途径和细胞增殖。这种蛋白质还与淀粉样蛋白前体蛋白 (APP) 相互作用并抑制淀粉样蛋白 β (Abeta) 的产生。已经鉴定出编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

CD74 基因产物(5)

mRNA Protein Name
NM_001025158.3 NP_001020329.1 HLA class II histocompatibility antigen gamma chain isoform c
NM_001025159.3 NP_001020330.1 HLA class II histocompatibility antigen gamma chain isoform a
NM_001364083.3 NP_001351012.1 HLA class II histocompatibility antigen gamma chain isoform d
NM_001364084.3 NP_001351013.1 HLA class II histocompatibility antigen gamma chain isoform e
NM_004355.4 NP_004346.1 HLA class II histocompatibility antigen gamma chain isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD4 receptor binding IPI
IPI: 通过物理相互作用推断
24942581 GOA
enables MHC class II protein binding, via antigen binding groove IDA
IDA: 通过直接分析推断
7477400 GOA
enables MHC class II protein complex binding IDA
IDA: 通过直接分析推断
1448172 GOA
enables amyloid-beta binding IPI
IPI: 通过物理相互作用推断
19849849 GOA
enables cytokine binding IPI
IPI: 通过物理相互作用推断
17567581 GOA
enables cytokine receptor activity IDA
IDA: 通过直接分析推断
17045821 GOA
enables macrophage migration inhibitory factor binding IPI
IPI: 通过物理相互作用推断
17045821 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17357109 GOA
enables protein folding chaperone IDA
IDA: 通过直接分析推断
7477400 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
IDA: 通过直接分析推断
17045821 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12782713 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
20198449 GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
IMP: 通过突变表型推断
17045821 GOA
involved in negative regulation of peptide secretion IDA
IDA: 通过直接分析推断
19849849 GOA
involved in negative regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
32855215 GOA
involved in positive regulation of B cell proliferation IMP
IMP: 通过突变表型推断
12782713 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
17045821 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
12782713 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
19423618 GOA
involved in positive regulation of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
12782713 GOA
involved in positive regulation of fibroblast proliferation IMP
IMP: 通过突变表型推断
12782713 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19423618 GOA
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
24569872 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
24569872 GOA
involved in positive regulation of kinase activity IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of macrophage migration inhibitory factor signaling pathway IMP
IMP: 通过突变表型推断
19665027 GOA
involved in positive regulation of monocyte differentiation IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: 通过突变表型推断
24569872 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
24942581 GOA
involved in positive regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
24942581 GOA
involved in prostaglandin biosynthetic process IDA
IDA: 通过直接分析推断
12782713 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
32855215 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
17045821 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
22952837 GOA
part of macrophage migration inhibitory factor receptor complex IDA
IDA: 通过直接分析推断
17045821 GOA
located in membrane IDA
IDA: 通过直接分析推断
12782713 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19423618 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19665027 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
19665027 GOA
located in vacuole IDA
IDA: 通过直接分析推断
19849849 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD74 蛋白结构

MHC2-interact

MHC2-interact: CLIP, MHC2 interacting (17 - 129)

MHCassoc_trimer

MHCassoc_trimer: Class II MHC-associated invariant chain trimerisation domain (136 - 207)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (221 - 271)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

HLA class II histocompatibility antigen gamma chain

CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

CD74 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD74 P04233 CXCR2 Homo sapiens P25025
Anti Tag CoIP
17435771
种属内
CD74 P04233 CXCR2 Homo sapiens P25025
Anti Bait CoIP
17435771
种属内
CD74 P04233 KPNB1 Homo sapiens Q14974
Pull Down
30833792
种属内
CD74 P04233 EIF3E Homo sapiens P60228
Pull Down
30833792
种属内
CD74 P04233 CXCR4 Homo sapiens P61073
Anti Tag CoIP
19665027
种属内
CD74 P04233 CXCR4 Homo sapiens P61073
Anti Bait CoIP
19665027
种属内
CD74 P04233 CD44 Homo sapiens P16070
Confocal
29190904
种属间
CD74 P04233 dnaK Escherichia coli P0A6Y8
Solid Phase Assay
17357109
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD74 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72931 CD74 Protein, Human (HEK293, His) NP_004346.1 (Q73-M232) ≥95%

关联疾病

疾病名称 别名
Mucinous Lung Adenocarcinoma
Mucinous Adenocarcinoma

Mucin-Producing Adenocarcinoma

Mucin-Secreting Adenocarcinoma

Mucin-Secreting Carcinoma

Mucous Carcinoma

Pseudomyxoma Peritonei With Unknown Primary Site

Adenocarcinoma, Mucinous
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99731 Milatuzumab Inhibitor 99.39% Phase 2
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N2245 Schisandrone Inhibitor 99.85% 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990728 Bezetabart Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CD74 VGNC VGNC:38972
Bos taurus CD74 VGNC VGNC:52227
Macaca mulatta CD74 VGNC VGNC:70779
Rattus norvegicus CD74 RGD RGD:2313
Felis catus CD74 VGNC VGNC:60638
Mus musculus CD74 MGD MGI:96534
Others CD74 NCBI
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