2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. IFNAR CD74 NO Synthase Arginase
  4. BG-136

BG-136 是一种可以从南极丛梗藻 (Durvillaea Antarctica) 中分离得到的先天性免疫刺激剂，能够在肿瘤微环境 (TME) 中同时刺激先天性免疫细胞和适应性免疫细胞的激活，从而发挥广谱抗肿瘤作用。

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BG-136 Chemical Structure

BG-136 Chemical Structure

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BG-136 相关抗体

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BG-136 is an innate immune stimulant isolated from Durvillaea Antarctica that can simultaneously stimulate the activation of both innate and adaptive immune cells in the tumor microenvironment (TME), exerting a broad-spectrum antitumor effect[1].

体内研究
(In Vivo)

BG136 (0.3 mg/kg, i.v. twice a week) 能够在 C57BL/6 J 小鼠结直肠癌 (CRC) 细胞系 MC38 同种异体肿瘤模型中体内抑制肿瘤生长，且未观察到体重减轻[1]。
BG136 (0.3 mg/kg, i.v. twice a week) 在 MC38 同源肿瘤模型中与抗 PD1 抗体 (200 μg per mouse, i.v. once a week) 联合使用，能增强抗 PD1 抗体肿瘤抑制作用，更有效地抑制肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 syngeneic tumor C57BL/6 J mice model[1].
Dosage: 0.3 mg/kg
Administration: i.v. twice a week alone, or BG136 in combination with PD1 antibody (200 μg per mouse, i.v. once a week)
Result: Significantly increased the infiltration of total CD45+ immune cells and CD8+ T cells in the tumor microenvironment (TME), as well as the proportion of cells expressing tumor necrosis factor α (TNFα) and granzyme B.
Significantly upregulated the antigen-presenting related genes CD74, H2-Ab1, and CD8b1, as well as the pro-inflammatory cytokine IFNγ.
Led to a significant decrease in Ki67 expression, indicating the inhibition of cell proliferation in the tumor microenvironment (TME), when used in combination with anti-PD1 antibody.
Was able to induce the gene expression of the pro-inflammatory cytokines IFNγ and TNFα, as well as the expression of the antitumor M1-like macrophage marker gene iNOS, and inhibit the expression of the tumor-promoting M2-like macrophage marker Arginase 1, when used in combination with anti-PD1 antibody.
分子量

4000-7000

结构分类
初始来源

Durvillaea antarctica
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BG-136 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BG-136BG136BG 136IFNARCD74NO SynthaseArginaseInterferon-α/β receptorInterferon-alpha/beta receptor HLA-DR-gammaInvariant polypeptide of major histocompatibility complex, class II antigen-associatedNitric oxide synthasesNOSImmune systemTumor microenvironmentAnti-tumoImmunotherapyTranscriptomicsC57BL/6 J miceColorectal cancer (CRC)MC38Inhibitorinhibitorinhibit

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产品名称：
BG-136
目录号：
HY-N15169
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