1. Gene
  2. MIIP - migration and invasion inhibitory protein Gene

MIIP - migration and invasion inhibitory protein Gene

中文名称:迁移侵袭抑制蛋白

种属: Homo sapiens

同用名: IIP45

基因 ID: 60672 | 基因类型: protein coding

关于 MIIP

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:12,019,498-12,032,045 (from NCBI)

This gene has 7 transcripts (splice variants) and 169 orthologues. Ubiquitous expression in bone marrow (RPKM 14.3), testis (RPKM 8.7) and 24 other tissues.

功能概要

该基因编码的蛋白质与致癌基因蛋白胰岛素样生长因子结合蛋白 2 相互作用,可作为细胞迁移和侵袭的抑制剂。该蛋白还与细胞分裂蛋白 20 相互作用,并可能参与调节有丝分裂进程。这种蛋白质可以通过抑制某些癌症的生长而起到肿瘤抑制因子的作用。[RefSeq 提供,2011 年 9 月]

This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]

MIIP 基因产物(1)

mRNA Protein Name
NM_021933.4 NP_068752.2 migration and invasion-inhibitory protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

migration and invasion-inhibitory protein

IGFBP2-binding protein

MIIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MIIP Q5JXC2 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
种属内
MIIP Q5JXC2 KRT34 Homo sapiens O76011
Y2H Array
32296183
种属内
MIIP Q5JXC2 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
种属内
MIIP Q5JXC2 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
种属内
MIIP Q5JXC2 KPRP Homo sapiens Q5T749
Y2H Array
32296183
种属内
MIIP Q5JXC2 MOB2 Homo sapiens Q70IA6
Validated Y2H
32296183
种属内
MIIP Q5JXC2 CHAT Homo sapiens P28329-3
Y2H Array
32814053
种属内
MIIP Q5JXC2 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
种属内
MIIP Q5JXC2 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
MIIP Q5JXC2 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
MIIP Q5JXC2 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
MIIP Q5JXC2 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
MIIP Q5JXC2 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
MIIP Q5JXC2 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
MIIP Q5JXC2 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
MIIP Q5JXC2 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
MIIP Q5JXC2 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
MIIP Q5JXC2 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
MIIP Q5JXC2 KCTD9 Homo sapiens Q7L273
Validated Y2H
32296183
种属内
MIIP Q5JXC2 MED28 Homo sapiens Q9H204
Validated Y2H
32296183
种属内
MIIP Q5JXC2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
MIIP Q5JXC2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
MIIP Q5JXC2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
MIIP Q5JXC2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
种属内
MIIP Q5JXC2 OIP5 Homo sapiens O43482
Y2H Array
32296183
种属内
MIIP Q5JXC2 MLLT3 Homo sapiens P42568
Anti Tag CoIP
33961781
种属内
MIIP Q5JXC2 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
32296183
种属内
MIIP Q5JXC2 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
种属内
MIIP Q5JXC2 TCHP Homo sapiens Q9BT92
Validated Y2H
32296183
种属内
MIIP Q5JXC2 TRIP6 Homo sapiens Q15654
Y2H Array
32296183
种属内
MIIP Q5JXC2 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
32296183
种属内
MIIP Q5JXC2 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
种属内
MIIP Q5JXC2 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
种属内
MIIP Q5JXC2 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prolapse Of Urethra

Urethrocele

Glioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MIIP MGD MGI:106506
Felis catus MIIP VGNC VGNC:63506
Macaca mulatta MIIP VGNC VGNC:74829
Rattus norvegicus MIIP RGD RGD:1587376
Bos taurus MIIP VGNC VGNC:31475
Canis familiaris MIIP VGNC VGNC:43234