MED28 - mediator complex subunit 28 Gene

中文名称：介体复合体亚基 28

种属: Homo sapiens

同用名: EG1; magicin; 1500003D12Rik

基因 ID: 80306 | 基因类型: protein coding

关于 MED28

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,614,641-17,634,105 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in ovary (RPKM 18.1), placenta (RPKM 17.9) and 25 other tissues.

功能概要

预测启用肌动蛋白结合活性。预计在平滑肌细胞分化和干细胞群维持的负调节上游或负调节内起作用。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable actin binding activity. Predicted to act upstream of or within negative regulation of smooth muscle cell differentiation and stem cell population maintenance. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MED28 基因产物(1)

mRNA	Protein	Name
NM_025205.5	NP_079481.2	mediator of RNA polymerase II transcription subunit 28

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10656681	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of core mediator complex	IPI IPI: 通过物理相互作用推断	24882805	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24882805	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MED28 蛋白结构

Med28

0
100
178 a.a.

蛋白主名

其他名称

mediator of RNA polymerase II transcription subunit 28

endothelial-derived gene 1

MED28 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240	Anti Bait CoIP	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Pull Down	15467741
Intra	MED28	Q9H204	NF2	Homo sapiens	P35240-1	Anti Tag CoIP	15467741
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Prey Pooling	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H Array	25416956
Intra	MED28	Q9H204	PUF60	Homo sapiens	Q9UHX1	Y2H	21516116
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	MED28	Q9H204	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	LCK	Homo sapiens	P06239	Protein Kinase Assay	16899217
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MIIP	Homo sapiens	Q5JXC2	Y2H Array	32296183
Cross	MED28	Q9H204	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MAGI3	Homo sapiens	Q5TCQ9	Peptide Array	16964398
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED17	Homo sapiens	Q9NVC6	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED27	Homo sapiens	Q6P2C8	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED6	Homo sapiens	O75586	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Prey Pooling	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Y2H Array	32296183
Intra	MED28	Q9H204	MED30	Homo sapiens	Q96HR3	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	24882805
Intra	MED28	Q9H204	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED28	Q9H204	GRB2	Homo sapiens	P62993	Far-WB	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Anti Bait CoIP	16899217
Intra	MED28	Q9H204	FYN	Homo sapiens	P06241	Y2H	16899217
Intra	MED28	Q9H204	YES1	Homo sapiens	P07947	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Pull Down	16899217
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Anti Bait CoIP	16964398
Intra	MED28	Q9H204	SRC	Homo sapiens	P12931	Peptide Array	16964398
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	MED28	Q9H204	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Cross	MED28	Q9H204	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Med23

Intellectual Disability, Autosomal Recessive 18

Autosomal Recessive Nonsyndromic Intellectual Disability-18

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08299	MED28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	MED28	VGNC	VGNC:107347
Rattus norvegicus	MED28	RGD	RGD:1305875
Canis familiaris	MED28	VGNC	VGNC:43135
Macaca mulatta	MED28	VGNC	VGNC:74569
Mus musculus	MED28	MGD	MGI:1914249
Bos taurus	MED28	VGNC	VGNC:31364

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MED28 - mediator complex subunit 28 Gene

关于 MED28

功能概要

MED28 基因产物(1)

MED28 蛋白结构

MED28 蛋白互作信息

关联疾病

直系同源

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MED28 - mediator complex subunit 28 Gene

关于 MED28

功能概要

MED28 基因产物(1)

MED28 蛋白结构

MED28 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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