MED27 - mediator complex subunit 27 Gene

中文名称：介体复合体亚基 27

种属: Homo sapiens

同用名: MED3; CRSP8; CRAP34; CRSP34; TRAP37; NEDSCAC

关于 MED27

功能概要

基因转录的激活是一个多步骤过程，由识别 DNA 中转录增强子位点的因素触发。这些因子与共激活因子一起通过 RNA 聚合酶 II 装置指导转录起始。该基因编码的蛋白质是 CRSP (SP1 激活所需的辅因子) 复合物的一个亚基，它与 TFIID 一起是 SP1 有效激活所必需的。这种蛋白质也是其他多亚基复合物的组成部分，例如甲状腺激素受体- (TR-) 相关蛋白，它与 TR 相互作用并促进 TR 在 DNA 模板上与起始因子和辅因子一起发挥功能。已经观察到该基因编码多种亚型的选择性剪接转录变体，并且该基因的假基因位于 5 号染色体的长臂上。[RefSeq 提供，2011 年 12 月]

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]