1. Gene
  2. MED30 - mediator complex subunit 30 Gene

MED30 - mediator complex subunit 30 Gene

中文名称:介体复合体亚基 30

种属: Homo sapiens

同用名: MED30S; THRAP6; TRAP25

基因 ID: 90390 | 基因类型: protein coding

关于 MED30

Cytogenetic location: 8q24.11 Genomic coordinates (GRCh38): 8:117,520,713-117,540,262 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in bone marrow (RPKM 9.2), lymph node (RPKM 5.0) and 24 other tissues.

功能概要

多蛋白 TRAP/介体复合物通过多种转录激活因子促进基因表达。 MED30 是该复合体的一个组成部分,似乎是后生动物特有的 (Baek 等人,2002 [PubMed 11909976]) 。[OMIM 提供,2010 年 11 月]

The multiprotein TRAP/Mediator complex facilitates gene expression through a wide variety of transcriptional activators. MED30 is a component of this complex that appears to be metazoan specific (Baek et al., 2002 [PubMed 11909976]).[supplied by OMIM, Nov 2010]

MED30 基因产物(3)

mRNA Protein Name
NM_001282986.2 NP_001269915.1 mediator of RNA polymerase II transcription subunit 30 isoform 2
NM_001363182.2 NP_001350111.1 mediator of RNA polymerase II transcription subunit 30 isoform 3
NM_080651.4 NP_542382.1 mediator of RNA polymerase II transcription subunit 30 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables nuclear thyroid hormone receptor binding IDA
IDA: 通过直接分析推断
10198638 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21784977 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
12218053 GOA
enables transcription coregulator activity IDA
IDA: 通过直接分析推断
10198638 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
10198638 GOA
involved in positive regulation of transcription initiation by RNA polymerase II IDA
IDA: 通过直接分析推断
12218053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of core mediator complex IPI
IPI: 通过物理相互作用推断
24882805 GOA
part of mediator complex IDA
IDA: 通过直接分析推断
10198638 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10235267 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MED30 蛋白结构

Med30

Med30: Mediator complex subunit 30 (29 - 177)

  • 0
  • 100
  • 178 a.a.
蛋白主名 其他名称

mediator of RNA polymerase II transcription subunit 30

TRAP/Mediator complex component TRAP25

MED30 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MED30 Q96HR3 DOCK8 Homo sapiens Q8NF50-2 25416956
种属内
MED30 Q96HR3 NAP1L2 Homo sapiens Q9ULW6 32296183
种属内
MED30 Q96HR3 MED28 Homo sapiens Q9H204
TAP
24981860
种属内
MED30 Q96HR3 MED28 Homo sapiens Q9H204 32296183
种属内
MED30 Q96HR3 NME7 Homo sapiens Q9Y5B8 32296183
种属内
MED30 Q96HR3 IFT20 Homo sapiens Q8IY31-3 32296183
种属内
MED30 Q96HR3 IFT20 Homo sapiens Q8IY31-3 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects

Cornelia De Lange Syndrome 4

CDLS4

Cornelia De Lange Syndrome, Type 4

Trichorhinophalangeal Syndrome, Type Ii

Langer-Giedion Syndrome

Lgs

Trichorhinophalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome Type 2

TRPS2

Monosomy 8q24.1

Chromosome 8q24.1 Deletion Syndrome

Deletion 8q24.1

Giedion-Langer Syndrome

Trichorhinophalangeal Dysplasia Type Ii

Langer Giedion Syndrome

Trps 2

Tricho-Rhino-Phalangeal Syndrome Type Ii

Trichorhinophalangeal Syndrome With Exostosis

Trps Ii

Tricho-Rhino-Phalangeal Syndrome 2

8q24.1 Microdeletion Syndrome

8q24.1 Deletion Syndrome

Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases

Acoustic Nerve Disease

Cochlear Nerve Diseases

Disturbance Of Vestibulocochlear Nerve

Auditory Nerve Disorder

Disorder Of Acoustovestibular Nerve

Disorder Of Eighth Nerve

Eighth Cranial Nerve Disorder

Disease Of Eighth Cranial Nerve

Disease Of Acoustic Nerve

Disease Of Auditory Nerve

Disorder Of 8th Cranial Nerve

Auditory Nerve Lesion

Cochlear Nerve Disorder

Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis

Herpes Zoster Oticus

Nervus Intermedius Neuralgia

Ramsay Hunt Syndrome Type 2

Geniculate Herpes Zoster

Geniculate Neuralgia

Herpes Zoster Auricularis

Herpetic Geniculate Ganglionitis

Ramsay Hunt Syndrome Type Ii

Ramsey Hunt Syndrome

Facial Nerve Palsy Due To Vzv

Facial Nerve Palsy Due To Herpes Zoster Infection

Facial Nerve Paralysis Due To Vzv

Hunt Syndrome

Hunt'S Syndrome

Ramsay Hunt Syndrome

Myoclonus And Ataxia

Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MED30 VGNC VGNC:43137
Bos taurus MED30 VGNC VGNC:31366
Mus musculus MED30 MGD MGI:1917040
Rattus norvegicus MED30 RGD RGD:1309369
Macaca mulatta MED30 VGNC VGNC:74556
Felis catus MED30 VGNC VGNC:63441
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