2. Gene
  3. CPN1 - carboxypeptidase N subunit 1 Gene

CPN1 - carboxypeptidase N subunit 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 N 亚基 1

种属: Homo sapiens

同用名: CPN; SCPN

基因 ID: 1369 | 基因类型: protein coding

关于 CPN1

Cytogenetic location: 10q24.2 Genomic coordinates (GRCh38): 10:100,042,193-100,081,869 (from NCBI)

This gene has 2 transcripts (splice variants), 196 orthologues, 7 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 18.6).

功能概要

羧肽酶 N 是一种血浆金属蛋白酶，可从肽和蛋白质的 C 末端切割碱性氨基酸。该酶在调节激肽和过敏毒素等肽方面很重要，也被称为激肽酶 1 和过敏毒素灭活剂。这种酶是由两个相同的调节亚基和两个相同的催化亚基组成的四聚体；该基因编码催化亚基。该基因的突变可能与由羧肽酶 N 缺乏引起的血管性水肿或慢性荨麻疹有关。[RefSeq 提供，2008 年 7 月]

Carboxypeptidase N is a plasma metallo-protease that cleaves basic Amino acids from the C terminal of Peptides and proteins. The Enzyme is important in the regulation of Peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This Enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from Carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

CPN1 基因产物(1)

mRNA Protein Name
NM_001308.3 NP_001299.1 carboxypeptidase N catalytic chain precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPN1 蛋白结构

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (34 - 329)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (342 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
蛋白主名 其他名称

carboxypeptidase N catalytic chain

anaphylatoxin inactivator

CPN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CPN1 P15169 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
种属内
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
CPN1 P15169 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Carboxypeptidase N Deficiency

Anaphylotoxin Inactivator Deficiency

Deficiency Of Carboxypeptidase B

CPND
Chronic Urticaria

Urticaria Chronic

Chronic Spontaneous Urticaria

Chronic Ordinary Urticaria
Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria
Urticaria

Nettle Rash

Hives

Wheal

Urticaria Nos
Inclusion Conjunctivitis

Chlamydial Conjunctivitis

Inclusion Blennorrhoea

Paratrachoma

Adult Inclusion Conjunctivitis

Inclusion Blenorrhea

Conjunctivitis, Inclusion

Neonatal Chlamydial Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Chronic Conjunctivitis Due To Chlamydia Trachomatis

Inclusion Conjunctivitis Due To Chlamydia Trachomatis

Acute Follicular Conjunctivitis, Chlamydial

Adult Chlamydial Keratoconjunctivitis
Lymphogranuloma Venereum

Climatic Or Tropical Bubo

Durand-Nicolas-Favre Disease

Lymphogranuloma Inguinale

Poradenitis Inguinale

Strumous Bubo

Lgv
Granuloma Inguinale

Donovanosis

Pudendal Ulcer

Granuloma Inguinale Tropicum

Granuloma Pudendi Tropicum
Ornithosis

Psittacosis

Chlamydial Pneumonia

Chlamydia Psittaci Infection

Chlamydia Psittaci
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03101 CPN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CPN1 MGD MGI:2135874
Rattus norvegicus CPN1 RGD RGD:70931
Canis familiaris CPN1 VGNC VGNC:39558
Macaca mulatta CPN1 VGNC VGNC:71462
Felis catus CPN1 VGNC VGNC:61127
Bos taurus CPN1 VGNC VGNC:27656
Others CPN1 NCBI
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