2. Gene
  3. RRAGA - Ras related GTP binding A Gene

RRAGA - Ras related GTP binding A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Ras 相关 GTP 结合 A

种属: Homo sapiens

同用名: FIP1; RAGA; FIP-1

基因 ID: 10670 | 基因类型: protein coding

关于 RRAGA

Cytogenetic location: 9p22.1 Genomic coordinates (GRCh38): 9:19,049,427-19,051,025 (from NCBI)

This gene has 1 transcript (splice variant), 175 orthologues, 3 paralogues and is associated with 1 phenotype.

功能概要

启用多项功能，包括 GTP 绑定活动；蛋白质二聚化活性；和泛素蛋白连接酶结合活性。参与多个过程，包括细胞对氨基酸饥饿的反应；自噬的负调控；和 TORC1 信号的正调控。位于溶酶体和细胞核中。与 GATOR1 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Colocalizes with GATOR1 complex. [provided by Alliance of Genome Resources, Apr 2022]

RRAGA 基因产物(1)

mRNA Protein Name
NM_006570.5 NP_006561.1 ras-related GTP-binding protein A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
7499430 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
31601708 GOA
enables phosphoprotein binding IDA
IDA: 通过直接分析推断
8995684 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8995684 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
11073942 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
14660641 GOA
enables protein-membrane adaptor activity IDA
IDA: 通过直接分析推断
31601708 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
25936802 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid starvation IMP
IMP: 通过突变表型推断
25936802 GOA
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
20381137 GOA
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
31601708 GOA
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
9394008 GOA
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
25936802 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
31601708 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
25936802 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
20381137 GOA
involved in protein localization to lysosome IDA
IDA: 通过直接分析推断
31601708 GOA
involved in protein localization to membrane IDA
IDA: 通过直接分析推断
31601708 GOA
involved in tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
8995684 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FNIP-folliculin RagC/D GAP IDA
IDA: 通过直接分析推断
36103527 GOA
part of GATOR1 complex IDA
IDA: 通过直接分析推断
25936802 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9394008 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
31601708 GOA
located in lysosome IDA
IDA: 通过直接分析推断
20381137 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
8995684 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9394008 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RRAGA 蛋白结构

Gtr1_RagA

Gtr1_RagA: Gtr1/RagA G protein conserved region (9 - 235)

  • 0
  • 100
  • 200
  • 313 a.a.
蛋白主名 其他名称

ras-related GTP-binding protein A

adenovirus E3 14.7 kDa-interacting protein 1

RRAGA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RRAGA Q7L523 DYNLT1 Homo sapiens P63172
Y2H Array
32296183
种属内
RRAGA Q7L523 DYNLT1 Homo sapiens P63172
Y2H Prey Pooling
32296183
种属内
RRAGA Q7L523 LAMTOR1 Homo sapiens Q6IAA8
Anti Bait CoIP
25561175
种属内
RRAGA Q7L523 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
BRET
37398436
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
33961781
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Y2H Pooling
16189514
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
28514442
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
BiLC
37398436
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
11073942
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Y2H
11073942
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25561175
种属内
RRAGA Q7L523 RRAGC Homo sapiens Q9HB90
Lumier
37398436
种属内
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
25561175
种属内
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
11073942
种属内
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
28514442
种属内
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Anti Tag CoIP
33961781
种属内
RRAGA Q7L523 RRAGD Homo sapiens Q9NQL2
Y2H
11073942
种属内
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
32433612
种属内
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25561175
种属内
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
种属内
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25567906
种属内
RRAGA Q7L523 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Premature Ovarian Failure 18

POF18

Primary Ovarian Insufficiency 18

Ovarian Failure, Premature, Type 18
Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome

Fibrofolliculomas With Trichodiscomas And Acrochordons

BHD

Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculoma Familial

Bhd Syndrome

Birt Hogg Dube Syndrome

Hornstein-Birt-Hogg-Dubé Syndrome

Multiple Fibrofolliculomas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12276 RRAGA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RRAGA RGD RGD:619804
Macaca mulatta RRAGA VGNC VGNC:77031
Felis catus RRAGA VGNC VGNC:64767
Mus musculus RRAGA MGD MGI:1915691
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