2. Gene
  3. SLC38A9 - solute carrier family 38 member 9 Gene

SLC38A9 - solute carrier family 38 member 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 38 成员 9

种属: Homo sapiens

同用名: SNAT9; URLC11

基因 ID: 153129 | 基因类型: protein coding

关于 SLC38A9

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,625,845-55,712,335 (from NCBI)

This gene has 26 transcripts (splice variants), 209 orthologues and 15 paralogues. Broad expression in placenta (RPKM 15.1), testis (RPKM 7.5) and 22 other tissues.

功能概要

启用 L-精氨酸跨膜转运蛋白活性和 L-亮氨酸跨膜转运蛋白活性。参与氨基酸跨膜转运；细胞对氨基酸刺激的反应；和 TOR 信号的正向调节。位于晚期内体和溶酶体膜。是溶酶体膜的组成部分。与 Ragulator 复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables L-arginine transmembrane transporter activity and L-leucine transmembrane transporter activity. Involved in amino acid transmembrane transport; cellular response to amino acid stimulus; and positive regulation of TOR signaling. Located in late endosome and lysosomal membrane. Is integral component of lysosomal membrane. Colocalizes with Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC38A9 基因产物(8)

mRNA Protein Name
NM_001258286.1 NP_001245215.1 sodium-coupled neutral amino acid transporter 9 isoform 2
NM_001258287.1 NP_001245216.1 sodium-coupled neutral amino acid transporter 9 isoform 3
NM_001282429.1 NP_001269358.1 sodium-coupled neutral amino acid transporter 9 isoform 4
NM_001349382.1 NP_001336311.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349383.1 NP_001336312.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349384.1 NP_001336313.1 sodium-coupled neutral amino acid transporter 9 isoform 1
NM_001349385.1 NP_001336314.1 sodium-coupled neutral amino acid transporter 9 isoform 5
NM_173514.4 NP_775785.2 sodium-coupled neutral amino acid transporter 9 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-arginine transmembrane transporter activity IDA
IDA: 通过直接分析推断
25567906 GOA
enables L-asparagine transmembrane transporter activity IDA
IDA: 通过直接分析推断
25561175 GOA
enables L-glutamine transmembrane transporter activity IDA
IDA: 通过直接分析推断
25561175 GOA
enables L-leucine transmembrane transporter activity IDA
IDA: 通过直接分析推断
29053970 GOA
enables amino acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
25561175 GOA
enables cholesterol binding IDA
IDA: 通过直接分析推断
28336668 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
30181260 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25561175 GOA
enables sterol sensor activity IDA
IDA: 通过直接分析推断
28336668 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-arginine transmembrane transport IDA
IDA: 通过直接分析推断
25567906 GOA
involved in amino acid transmembrane transport IDA
IDA: 通过直接分析推断
25567906 GOA
involved in asparagine transport IDA
IDA: 通过直接分析推断
25561175 GOA
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
25561175 GOA
involved in glutamine transport IDA
IDA: 通过直接分析推断
25561175 GOA
involved in positive regulation of TOR signaling IDA
IDA: 通过直接分析推断
25561175 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
28336668 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FNIP-folliculin RagC/D GAP IDA
IDA: 通过直接分析推断
36103527 GOA
part of Ragulator complex IDA
IDA: 通过直接分析推断
25561175 GOA
located in late endosome IDA
IDA: 通过直接分析推断
25561175 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
30956113 GOA
located in lysosomal membrane IMP
IMP: 通过突变表型推断
29053970 GOA
located in lysosome IDA
IDA: 通过直接分析推断
25561175 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC38A9 蛋白结构

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (119 - 239)

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (299 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
蛋白主名 其他名称

sodium-coupled neutral amino acid transporter 9

putative sodium-coupled neutral amino acid transporter 9

SLC38A9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC38A9 Q8NBW4 LAMTOR3 Homo sapiens Q9UHA4
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
25567906
Intra SLC38A9 Q8NBW4 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25567906
Intra SLC38A9 Q8NBW4 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
25567906
Intra SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25567906
Intra SLC38A9 Q8NBW4 LAMTOR1 Homo sapiens Q6IAA8
Anti Bait CoIP
25561175
Intra SLC38A9 Q8NBW4 RRAGA Homo sapiens Q7L523
Anti Bait CoIP
25561175
Intra SLC38A9 Q8NBW4 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25561175
Intra SLC38A9 Q8NBW4 RRAGB Homo sapiens Q5VZM2
Anti Tag CoIP
25561175
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukodystrophy, Hypomyelinating, 3

Hypomyelinating Leukodystrophy 3

HLD3

Pelizaeus-Merzbacher-Like Disease Due To Aimp1 Mutation

Leukodystrophy, Hypomyelinating 3

Perinatal Sudanophilic Leukodystrophy

Leukodystrophy, Hypomyelinating, Type 3

Pelizaeus-Merzbacher-Like Disease, Autosomal Recessive, 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13227 SLC38A9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC38A9 MGD MGI:1918839
Felis catus SLC38A9 VGNC VGNC:65352
Bos taurus SLC38A9 VGNC VGNC:34856
Canis familiaris SLC38A9 VGNC VGNC:46399
Rattus norvegicus SLC38A9 RGD RGD:1311881
Macaca mulatta SLC38A9 VGNC VGNC:77574
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