2. Gene
  3. LAMTOR5 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Gene

LAMTOR5 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：晚期内体/溶酶体衔接子、MAPK 和 MTOR 激活因子 5

种属: Homo sapiens

同用名: XIP; HBXIP

基因 ID: 10542 | 基因类型: protein coding

关于 LAMTOR5

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,401,253-110,407,924 (from NCBI)

This gene has 7 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in kidney (RPKM 162.7), bone marrow (RPKM 53.1) and 24 other tissues.

功能概要

该基因编码的蛋白质与乙型肝炎病毒 X 蛋白 (HBx) 的 C 末端特异性复合。这种蛋白质的功能是负向调节 HBx 活性，从而改变病毒的复制生命周期。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

LAMTOR5 基因产物(2)

mRNA Protein Name
NM_001382293.1 NP_001369222.1 ragulator complex protein LAMTOR5 isoform 2
NM_006402.3 NP_006393.2 ragulator complex protein LAMTOR5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
22980980 GOA
contributes to molecular adaptor activity IDA
IDA: 通过直接分析推断
22980980 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12773388 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
22980980 GOA
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
22980980 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
12773388 GOA
acts upstream of or within positive regulation of NF-kappaB transcription factor activity IGI
IGI: 通过遗传相互作用推断
21343296 GOA
acts upstream of positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21343296 GOA
involved in positive regulation of TOR signaling IMP
IMP: 通过突变表型推断
22980980 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
28935770 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
21343296 GOA
acts upstream of positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
21343296 GOA
involved in positive regulation of interleukin-8 production IGI
IGI: 通过遗传相互作用推断
21343296 GOA
involved in positive regulation of protein localization to nucleus IDA
IDA: 通过直接分析推断
21343296 GOA
involved in protein localization to lysosome IMP
IMP: 通过突变表型推断
22980980 GOA
involved in regulation of cell size IMP
IMP: 通过突变表型推断
22980980 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FNIP-folliculin RagC/D GAP IDA
IDA: 通过直接分析推断
36103527 GOA
part of Ragulator complex IDA
IDA: 通过直接分析推断
22980980 GOA
part of Ragulator complex IPI
IPI: 通过物理相互作用推断
28935770 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12773388 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
29158492 GOA
located in lysosome IDA
IDA: 通过直接分析推断
22980980 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
12773388 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ragulator complex protein LAMTOR5

HBV X-interacting protein

LAMTOR5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Validated Y2H
32814053
Intra LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Y2H Array
32814053
Intra LAMTOR5 O43504 FKBP1A Homo sapiens Q0VDC6
Y2H Pooling
32814053
Intra LAMTOR5 O43504 SARS1 Homo sapiens P49591
Validated Y2H
32814053
Intra LAMTOR5 O43504 SARS1 Homo sapiens P49591
Y2H Pooling
32814053
Intra LAMTOR5 O43504 SARS1 Homo sapiens P49591
Y2H Array
32814053
Intra LAMTOR5 O43504 AK6 Homo sapiens Q9Y3D8
Y2H Array
25416956
Intra LAMTOR5 O43504 AK6 Homo sapiens Q9Y3D8
Y2H Prey Pooling
25416956
Intra LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra LAMTOR5 O43504 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra LAMTOR5 O43504 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra LAMTOR5 O43504 GSN Homo sapiens P06396
Y2H Array
32814053
Intra LAMTOR5 O43504 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Validated Y2H
32814053
Intra LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Y2H Array
32814053
Intra LAMTOR5 O43504 HSPA2 Homo sapiens P54652
Y2H Pooling
32814053
Intra LAMTOR5 O43504 BIRC5 Homo sapiens O15392
Validated Y2H
32296183
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Y2H Prey Pooling
32296183
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
33961781
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
MAPPIT
32296183
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Validated Y2H
32296183
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Affinity Chrom
22980980
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Y2H Array
32296183
Intra LAMTOR5 O43504 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25561175
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Prey Pooling
32296183
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Validated Y2H
32296183
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Array
25416956
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Pooling
16169070
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Array
32296183
Intra LAMTOR5 O43504 ZBTB16 Homo sapiens Q05516
Y2H Fragment Pooling
23414517
Intra LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra LAMTOR5 O43504 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
32814053
Intra LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32814053
Intra LAMTOR5 O43504 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32814053
Intra LAMTOR5 O43504 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra LAMTOR5 O43504 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra LAMTOR5 O43504 TCAP Homo sapiens O15273
Y2H Fragment Pooling
23414517
Intra LAMTOR5 O43504 TCAP Homo sapiens O15273
Validated Y2H
32296183
Intra LAMTOR5 O43504 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
Intra LAMTOR5 O43504 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
Cross LAMTOR5 O43504 Q9WMX2-PRO_0000037547 Hepatitis C virus Q9WMX2-PRO_0000037547
Pull Down
24169621
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Lobomycosis

Cutaneous Blastomycosis

Cutaneous Lobomycosis

Infection By Loboa Loboi

Lobo Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07517 LAMTOR5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LAMTOR5 RGD RGD:1305005
Felis catus LAMTOR5 VGNC VGNC:82532
Bos taurus LAMTOR5 VGNC VGNC:55244
Mus musculus LAMTOR5 MGD MGI:1915826
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