2. Gene
  3. LAMTOR4 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Gene

LAMTOR4 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：晚期内体/溶酶体衔接子、MAPK 和 MTOR 激活因子 4

种属: Homo sapiens

同用名: C7orf59

基因 ID: 389541 | 基因类型: protein coding

关于 LAMTOR4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,148,918-100,154,203 (from NCBI)

This gene has 12 transcripts (splice variants) and 181 orthologues. Ubiquitous expression in skin (RPKM 36.0), spleen (RPKM 29.2) and 25 other tissues.

功能概要

有助于胍基核苷酸交换因子活性和分子接头活性。参与多个过程，包括细胞对氨基酸刺激的反应； TOR 信号的正调控；和蛋白质定位到溶酶体。位于溶酶体中。 Ragulator 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including cellular response to amino acid stimulus; positive regulation of TOR signaling; and protein localization to lysosome. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

LAMTOR4 基因产物(6)

mRNA Protein Name
NM_001008395.4 NP_001008396.1 ragulator complex protein LAMTOR4 isoform 1
NM_001318236.2 NP_001305165.1 ragulator complex protein LAMTOR4 isoform 2
NM_001318237.2 NP_001305166.1 ragulator complex protein LAMTOR4 isoform 3
NM_001394587.1 NP_001381516.1 ragulator complex protein LAMTOR4 isoform 4
NM_001394588.1 NP_001381517.1 ragulator complex protein LAMTOR4 isoform 5
NM_001394589.1 NP_001381518.1 ragulator complex protein LAMTOR4 isoform 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
22980980 GOA
contributes to molecular adaptor activity IDA
IDA: 通过直接分析推断
22980980 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22980980 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
22980980 GOA
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
22980980 GOA
involved in positive regulation of TOR signaling IMP
IMP: 通过突变表型推断
22980980 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
28935770 GOA
involved in protein localization to lysosome IMP
IMP: 通过突变表型推断
22980980 GOA
involved in regulation of cell size IMP
IMP: 通过突变表型推断
22980980 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FNIP-folliculin RagC/D GAP IDA
IDA: 通过直接分析推断
36103527 GOA
part of Ragulator complex IDA
IDA: 通过直接分析推断
22980980 GOA
part of Ragulator complex IPI
IPI: 通过物理相互作用推断
28935770 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
29158492 GOA
located in lysosome IDA
IDA: 通过直接分析推断
22980980 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

ragulator complex protein LAMTOR4

UPF0539 protein C7orf59

LAMTOR4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
25561175
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
X-Ray Diffraction
29123114
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Y2H Prey Pooling
25416956
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Light Scattering
29123114
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Affinity Chrom
22980980
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Anti Tag CoIP
33961781
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Validated Y2H
25416956
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Y2H Prey Pooling
32296183
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Y2H Array
25416956
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Y2H Fragment Pooling
23414517
Intra LAMTOR4 Q0VGL1 LAMTOR5 Homo sapiens O43504
Y2H Array
32296183
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
25561175
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
Confocal
22980980
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
22980980
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
BRET
37398436
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
Anti Tag CoIP
33961781
Intra LAMTOR4 Q0VGL1 LAMTOR1 Homo sapiens Q6IAA8
Affinity Chrom
22980980
Intra LAMTOR4 Q0VGL1 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
Intra LAMTOR4 Q0VGL1 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Newfoundland Rod-Cone Dystrophy

Newfoundland Cone-Rod Dystrophy

NFRCD

Rod-Cone Dystrophy Newfoundland
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07516 LAMTOR4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LAMTOR4 VGNC VGNC:74178
Canis familiaris LAMTOR4 VGNC VGNC:42579
Felis catus LAMTOR4 VGNC VGNC:80588
Mus musculus LAMTOR4 MGD MGI:1913346
Bos taurus LAMTOR4 VGNC VGNC:30782
Rattus norvegicus LAMTOR4 RGD RGD:1309735
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