RRAGC - Ras related GTP binding C Gene

中文名称：Ras 相关 GTP 结合 C

种属: Homo sapiens

同用名: GTR2; RAGC; TIB929

基因 ID: 64121 | 基因类型: protein coding

关于 RRAGC

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:38,838,198-38,859,772 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 23.8), placenta (RPKM 15.8) and 25 other tissues.

功能概要

该基因编码 GTR/RAG GTP 结合蛋白家族的成员。编码的蛋白质是一种单体鸟嘌呤核苷酸结合蛋白，它与 RRAGA 和 RRAGB 形成异二聚体，主要定位于细胞质。编码的蛋白质促进 mTOR 复合物的细胞内定位。可变剪接导致多个转录本变体。[RefSeq 提供，2012 年 12 月]

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

RRAGC 基因产物(2)

mRNA	Protein	Name
NM_001271851.2	NP_001258780.1	ras-related GTP-binding protein C isoform 2
NM_022157.4	NP_071440.1	ras-related GTP-binding protein C isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	11073942	GOA
enables GDP binding	IMP IMP: 通过突变表型推断	22424946	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	11073942	GOA
enables GTP binding	IMP IMP: 通过突变表型推断	22424946	GOA
enables GTPase activity	IDA IDA: 通过直接分析推断	11073942	GOA
enables GTPase binding	IPI IPI: 通过物理相互作用推断	22424946	GOA
enables enzyme-substrate adaptor activity	IDA IDA: 通过直接分析推断	32612235	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	32612235	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11073942	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	11073942	GOA
enables protein-membrane adaptor activity	IDA IDA: 通过直接分析推断	31601708	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to amino acid starvation	IGI IGI: 通过遗传相互作用推断	23723238	GOA
involved in cellular response to nutrient levels	IDA IDA: 通过直接分析推断	31601708	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	31601708	GOA
involved in positive regulation of TORC1 signaling	IMP IMP: 通过突变表型推断	26691987	GOA
involved in protein localization to lysosome	IDA IDA: 通过直接分析推断	31601708	GOA
involved in protein localization to membrane	IDA IDA: 通过直接分析推断	31601708	GOA
involved in regulation of TOR signaling	IGI IGI: 通过遗传相互作用推断	23723238	GOA
involved in regulation of TORC1 signaling	IMP IMP: 通过突变表型推断	27222292	GOA
involved in response to amino acid	IMP IMP: 通过突变表型推断	27222292	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FNIP-folliculin RagC/D GAP	IDA IDA: 通过直接分析推断	32612235	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	11073942	GOA
is active in lysosomal membrane	IDA IDA: 通过直接分析推断	31601708	GOA
located in lysosome	IDA IDA: 通过直接分析推断	20381137	GOA
located in nucleus	IDA IDA: 通过直接分析推断	11073942	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RRAGC 蛋白结构

Gtr1_RagA

0
100
200
300
399 a.a.

蛋白主名

其他名称

ras-related GTP-binding protein C

GTPase-interacting protein 2

RRAGC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RRAGC	Q9HB90	NSL1	Homo sapiens	Q96IY1	Lumier	37398436
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	BRET	37398436
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	22424946
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	BiLC	37398436
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Affinity Chrom	22980980
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25561175
种属内	RRAGC	Q9HB90	LAMTOR1	Homo sapiens	Q6IAA8	Anti Tag CoIP	25567906
种属内	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Y2H	11073942
种属内	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Anti Tag CoIP	11073942
种属内	RRAGC	Q9HB90	RRAGA	Homo sapiens	Q7L523	Pull Down	11073942
种属内	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Bait CoIP	20381137
种属内	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	22424946
种属内	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	25561175
种属内	RRAGC	Q9HB90	RRAGB	Homo sapiens	Q5VZM2	Anti Tag CoIP	25567906
种属内	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25567906
种属内	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Bait CoIP	25567906
种属内	RRAGC	Q9HB90	SLC38A9	Homo sapiens	Q8NBW4	Anti Tag CoIP	25561175

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Birt-Hogg-Dube Syndrome

Hornstein-Knickenberg Syndrome	Fibrofolliculomas With Trichodiscomas And Acrochordons
BHD	Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculoma Familial	Bhd Syndrome
Birt Hogg Dube Syndrome	Hornstein-Birt-Hogg-Dubé Syndrome
Multiple Fibrofolliculomas

Retinitis Pigmentosa 60

RP60	Retinitis Pigmentosa, Type 60

Familial Renal Oncocytoma

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Fanconi Anemia, Complementation Group C

Fanconi Anemia Complementation Group C	FANCC
Facc	Fac
Fa3	Fanconi Pancytopenia Type 3
Fanconi Pancytopenia, Type 3	Faces Syndrome
Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies	Friedman-Goodman Syndrome
Abnormality Of The Face

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12278	RRAGC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RRAGC	VGNC	VGNC:45756
Mus musculus	RRAGC	MGD	MGI:1858751
Rattus norvegicus	RRAGC	RGD	RGD:1311760
Bos taurus	RRAGC	VGNC	VGNC:34160
Macaca mulatta	RRAGC	VGNC	VGNC:77060
Felis catus	RRAGC	VGNC	VGNC:64769

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RRAGC - Ras related GTP binding C Gene

关于 RRAGC

功能概要

RRAGC 基因产物(2)

RRAGC 蛋白结构

RRAGC 蛋白互作信息

关联疾病

直系同源

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RRAGC - Ras related GTP binding C Gene

关于 RRAGC

功能概要

RRAGC 基因产物(2)

RRAGC 蛋白结构

RRAGC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z