NSL1 - NSL1 component of MIS12 kinetochore complex Gene

中文名称：MIS12 着丝粒复合体的 NSL1 成分

种属: Homo sapiens

同用名: DC8; MIS14; C1orf48

基因 ID: 25936 | 基因类型: protein coding

关于 NSL1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,726,153-212,791,777 (from NCBI)

This gene has 6 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in brain (RPKM 2.0), lymph node (RPKM 1.8) and 25 other tissues.

功能概要

该基因编码的蛋白质具有两个卷曲螺旋结构域，定位于着丝粒，着丝粒是染色体相关结构，附着于微管并在细胞分裂过程中介导染色体运动。编码的蛋白质是保守蛋白质复合物的一部分，该复合物包括两个含染色质域的蛋白质和着丝粒外板的一个成分。该蛋白质复合物被提议用于桥接着丝粒异染色质与外部着丝粒结构。已发现该基因编码不同异构体的多个转录变体。 X 染色体上该基因的 3' UTR 区域有一个假基因。[RefSeq 提供，2014 年 7 月]

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]

NSL1 基因产物(5)

mRNA	Protein	Name
NM_001042549.2	NP_001036014.1	kinetochore-associated protein NSL1 homolog isoform 2
NM_001297736.2	NP_001284665.1	kinetochore-associated protein NSL1 homolog isoform 3
NM_001297737.2	NP_001284666.1	kinetochore-associated protein NSL1 homolog isoform 4
NM_001297739.2	NP_001284668.1	kinetochore-associated protein NSL1 homolog isoform 5
NM_015471.4	NP_056286.3	kinetochore-associated protein NSL1 homolog isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15502821	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MIS12/MIND type complex	IDA IDA: 通过直接分析推断	16585270	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	15371340	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	24530301	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NSL1 蛋白结构

Mis14

0
100
200
281 a.a.

蛋白主名

其他名称

kinetochore-associated protein NSL1 homolog

NSL1, MIND kinetochore complex component, homolog

NSL1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NSL1	Q96IY1	DSN1	Homo sapiens	Q9H410	Lumier	37398436
Intra	NSL1	Q96IY1	DSN1	Homo sapiens	Q9H410	BRET	37398436
Intra	NSL1	Q96IY1	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	33961781
Intra	NSL1	Q96IY1	DSN1	Homo sapiens	Q9H410	Anti Tag CoIP	28514442
Intra	NSL1	Q96IY1	DSN1	Homo sapiens	Q9H410	BiLC	37398436
Intra	NSL1	Q96IY1	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	NSL1	Q96IY1	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	NSL1	Q96IY1	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma

Malaria

Malaria, Susceptibility To	Malaria, Resistance To
Malaria, Cerebral	Cerebral Malaria
Malaria, Severe, Susceptibility To	Malaria, Severe, Resistance To
Malaria, Cerebral, Susceptibility To	Induced Malaria
Malaria, Vivax, Protection Against	Malaria, Severe
Malaria, Cerebral, Reduced Risk Of	Malaria, Protection Against
Resistance To Malaria Due To G6pd Deficiency	Malaria Due To G6pd Deficiency
Malarial Encephalitis	CM
Malaria Cerebral	Susceptibility To Malaria
Acute Pernicious Fever	Aestivo-Autumnal Fever
Aestivo Autumnal Malaria	Chagres Fever
Continued Malaria Fever	Estivo-Autumnal Fever
Estivo-Autumnal Malaria	Estivo-Autumnal Malarial Fever
Falciparum Fever	Malignant Tertian Fever
Malignant Tertian Malaria	Pernicious Intermittent Fever
Pernicious Malaria	Quotidian Malaria
Subtertian Fever	Subtertian Malaria Fever
Subtertian Malignant Tertian Malaria	Tropical Malaria
Algid Malaria	Bilious Haemoglobinuric Fever
Black Water Fever	Blackwater Fever
Malarial Blackwater Fever	Severe Malarial Falciparum
West African Fever	Malarial Haematinuria
Haemoglobinuric Fever	Haemoglobinuric Malaria
Severe Plasmodium Falciparum Malaria	Malarial Haemoglobinuria
Malarial Haematuria	Falciparum Malaria [Malignant Tertian]
Malaria Tropica	Malarial Shock
Chagres Virus Disease	Malignant Malaria
Mtm - [Malignant Tertian Malaria]	Tm -[Malignant Tertian Malaria]
Panama Fever	St - [Subtertian Malaria]
Malarial Quotidian	Benign Tertian Malaria
Tertian Ague	Vivax Fever
Plasmodium Vivax Malaria Nos	Btm - [Benign Tertian Malaria]
Bt - [Benign Tertian Malaria]	Vivax Malaria
Benign Tertian Vivax Malaria	Tertian Malaria
Quartan Malaria	Quartan Ague
Quartan Fever	Plasmodium Malariae Malaria Nos
Quartan Malarial	Malaria By Plasmodium Malariae
Malariae Malaria	Ovale Tertian Malaria
Plasmodium Ovale Fever	Malaria Fever By Plasmodium Ovale
Ovale Malaria	Malaria By Plasmodium Ovale
Malarial Ovale	Marsh Fever
Remittent Congestive Fever	Coastal Fever
Remittent Gastric Fever	Miasmatic Fever
Congestive Remittent Fever	Intermittent Fever
Jungle Fever	Paludism
Cameroon Fever	Ague
Corsican Fever	Intermittent Bilious Fever
Disease Due To Plasmodiidae	Malarial Fever
Plasmodiosis	Remittent Fever
Roman Fever	Malaria Fever Nos
Malaria Nos	Paludal Fever
Clinically Diagnosed Malaria	Clinically Diagnosed Malaria Without Parasitological Confirmation
Congestive Fever	Malarial Cachexia
Marsh Cachexia	Paludal Cachexia
Recurrent Malaria	Remittent Malaria

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09595	NSL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	NSL1	VGNC	VGNC:32277
Felis catus	NSL1	VGNC	VGNC:63889
Canis familiaris	NSL1	VGNC	VGNC:43986
Rattus norvegicus	NSL1	RGD	RGD:1562052
Macaca mulatta	NSL1	VGNC	VGNC:75454
Mus musculus	NSL1	MGD	MGI:2685830

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NSL1 - NSL1 component of MIS12 kinetochore complex Gene

关于 NSL1

功能概要

NSL1 基因产物(5)

NSL1 蛋白结构

NSL1 蛋白互作信息

关联疾病

直系同源

热门区域

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NSL1 - NSL1 component of MIS12 kinetochore complex Gene

关于 NSL1

功能概要

NSL1 基因产物(5)

NSL1 蛋白结构

NSL1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z