DSN1 - DSN1 component of MIS12 kinetochore complex Gene

中文名称：MIS12 着丝粒复合体的 DSN1 成分

种属: Homo sapiens

同用名: KNL3; MIS13; hKNL-3; C20orf172; dJ469A13.2

基因 ID: 79980 | 基因类型: protein coding

关于 DSN1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,751,795-36,773,763 (from NCBI)

This gene has 10 transcripts (splice variants) and 174 orthologues. Broad expression in testis (RPKM 11.7), lymph node (RPKM 6.7) and 24 other tissues.

功能概要

该基因编码一种着丝粒蛋白，作为微型染色体不稳定性 12 着丝粒复合体的一部分发挥作用。编码的蛋白质是正确的着丝粒组装和细胞周期进展所必需的。可变剪接导致多个转录本变体。[RefSeq 提供，2009 年 2 月]

This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

DSN1 基因产物(5)

mRNA	Protein	Name
NM_001145315.2	NP_001138787.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145316.2	NP_001138788.1	kinetochore-associated protein DSN1 homolog isoform 1
NM_001145317.2	NP_001138789.1	kinetochore-associated protein DSN1 homolog isoform 2
NM_001145318.2	NP_001138790.1	kinetochore-associated protein DSN1 homolog isoform 3
NM_024918.4	NP_079194.3	kinetochore-associated protein DSN1 homolog isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15371340	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MIS12/MIND type complex	IDA IDA: 通过直接分析推断	16585270	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	15371340	GOA
part of outer kinetochore	IDA IDA: 通过直接分析推断	24530301	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DSN1 蛋白结构

MIS13

0
100
200
300
356 a.a.

蛋白主名

其他名称

kinetochore-associated protein DSN1 homolog

DSN1 homolog, MIS12 kinetochore complex component

DSN1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	GMS	23334297
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	24981860
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	26496610
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	TAP	27705803
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BRET	37398436
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	BiLC	37398436
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	33961781
种属内	DSN1	Q9H410	MIS12	Homo sapiens	Q9H081	Anti Tag CoIP	28514442
种属内	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Pooling	32814053
种属内	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Validated Y2H	32814053
种属内	DSN1	Q9H410	ATP5PB	Homo sapiens	P24539	Y2H Array	32814053
种属内	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
种属内	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
种属内	DSN1	Q9H410	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
种属内	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
种属内	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
种属内	DSN1	Q9H410	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Lumier	37398436
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BRET	37398436
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	GMS	23334297
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	24981860
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	TAP	27705803
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	BiLC	37398436
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	33961781
种属内	DSN1	Q9H410	NSL1	Homo sapiens	Q96IY1	Anti Tag CoIP	26496610
种属内	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
种属内	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
种属内	DSN1	Q9H410	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
种属内	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
种属内	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
种属内	DSN1	Q9H410	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
种属内	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Array	32814053
种属内	DSN1	Q9H410	BGN	Homo sapiens	P21810	Y2H Pooling	32814053
种属内	DSN1	Q9H410	BGN	Homo sapiens	P21810	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Colon Small Cell Carcinoma

Colonic Small Cell Carcinoma

Colon Small Cell Neuroendocrine Carcinoma

Arts Syndrome

ARTS	Mrxsarts
Ataxia, Fatal X-Linked, With Deafness And Loss Of Vision	Mrxs18
Lethal Ataxia With Deafness And Optic Atrophy	Fatal X-Linked Ataxia With Deafness And Loss Of Vision
Mental Retardation, X-Linked, Syndromic, Arts Type	Mental Retardation, X-Linked, Syndromic 18
Syndromic X-Linked Mental Retardation 18	Syndromic X-Linked Mental Retardation Arts Type
Lethal Ataxia-Deafness-Optic Atrophy	X-Linked Fatal Ataxia With Deafness And Loss Of Vision
Ataxia-Deafness-Optic Atrophy, Lethal	Lethal Ataxia With Hearing Loss And Optic Atrophy
Art

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04025	DSN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	DSN1	VGNC	VGNC:71846
Canis familiaris	DSN1	VGNC	VGNC:40109
Bos taurus	DSN1	VGNC	VGNC:28224
Mus musculus	DSN1	MGD	MGI:1914184
Felis catus	DSN1	VGNC	VGNC:61639
Rattus norvegicus	DSN1	RGD	RGD:1565179

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DSN1 - DSN1 component of MIS12 kinetochore complex Gene

关于 DSN1

功能概要

DSN1 基因产物(5)

DSN1 蛋白结构

DSN1 蛋白互作信息

关联疾病

直系同源

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DSN1 - DSN1 component of MIS12 kinetochore complex Gene

关于 DSN1

功能概要

DSN1 基因产物(5)

DSN1 蛋白结构

DSN1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z