RRAGB - Ras related GTP binding B Gene

中文名称：Ras 相关 GTP 结合 B

种属: Homo sapiens

同用名: RAGB; bA465E19.1

关于 RRAGB

功能概要

Ras 同源 GTPases 构成了一大类信号转导器，它们在激活的 GTP 结合状态和失活的 GDP 结合状态之间交替。这些蛋白质代表由 GTP 交换因子和刺激其内在 GTP 酶活性的因子操作的细胞开关。 Ras 超家族的所有 GTPases 都存在六个参与 GTP/GDP 结合的保守基序，其中三个是磷酸盐/镁结合位点 (PM1-PM3) ，三个是鸟嘌呤核苷酸结合位点 (G1 -G3) .已经识别出编码不同亚型的转录变体。[RefSeq 提供，2008 年 7 月]

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]