SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

中文名称：SEC13 同源物、核孔和 COPII 涂层复合物成分

种属: Homo sapiens

同用名: SEC13R; npp-20; SEC13L1; D3S1231E

基因 ID: 6396 | 基因类型: protein coding

关于 SEC13

Cytogenetic location: 3p25.3 Genomic coordinates (GRCh38): 3:10,300,931-10,321,112 (from NCBI)

This gene has 19 transcripts (splice variants), 220 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 31.7), small intestine (RPKM 28.0) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 WD 重复蛋白的 SEC13 家族。它是内质网和核孔复合体的组成部分。它与酵母 SEC13 蛋白具有相似性，后者是蛋白质转运过程中内质网囊泡生物发生所必需的。已发现多个选择性剪接的转录本变体。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene belongs to the SEC13 family of WD-repeat proteins. It is a constituent of the endoplasmic reticulum and the nuclear pore complex. It has similarity to the yeast SEC13 protein, which is required for vesicle biogenesis from endoplasmic reticulum during the transport of proteins. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2008]

SEC13 基因产物(5)

mRNA	Protein	Name
NM_001136026.3	NP_001129498.1	protein SEC13 homolog isoform 3
NM_001136232.3	NP_001129704.1	protein SEC13 homolog isoform 2
NM_001278946.2	NP_001265875.1	protein SEC13 homolog isoform 5
NM_030673.4	NP_109598.2	protein SEC13 homolog isoform 4
NM_183352.3	NP_899195.1	protein SEC13 homolog isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	18160040	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15146057	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in COPII-coated vesicle cargo loading	IDA IDA: 通过直接分析推断	17499046	GOA
involved in cellular response to nutrient levels	IDA IDA: 通过直接分析推断	35831510	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	35831510	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COPII vesicle coat	IDA IDA: 通过直接分析推断	17499046	GOA
part of GATOR2 complex	IDA IDA: 通过直接分析推断	35831510	GOA
colocalizes with kinetochore	IDA IDA: 通过直接分析推断	15146057	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	28199306	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	15146057	GOA
part of nuclear pore outer ring	IDA IDA: 通过直接分析推断	17360435	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEC13 蛋白结构

WD40

0
100
200
300
322 a.a.

蛋白主名

其他名称

protein SEC13 homolog

GATOR complex protein SEC13

SEC13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7-2	Validated Y2H	25416956
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7-2	Y2H Prey Pooling	25416956
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	33961781
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Y2H Array	27194810
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	28514442
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	28514442
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	33961781
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Anti Tag CoIP	35271311
Intra	SEC13	P55735	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	35271311
Intra	SEC13	P55735	NUP37	Homo sapiens	Q8NFH4	Anti Tag CoIP	35271311
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Anti Tag CoIP	33961781
Intra	SEC13	P55735	SEH1L	Homo sapiens	Q96EE3	Y2H Array	27194810
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	X-Ray Diffraction	18160040
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	GMS	18160040
Cross	SEC13	P55735	NUP145	Saccharomyces cerevisiae	P49687	Y2H Array	27194810
Intra	SEC13	P55735	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	35271311
Intra	SEC13	P55735	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	33961781
Intra	SEC13	P55735	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956
Intra	SEC13	P55735	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	SEC13	P55735	SEC16B	Homo sapiens	Q96JE7	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Craniolenticulosutural Dysplasia

Boyadjiev-Jabs Syndrome	CLSD
Cranio-Lenticulo-Sutural Dysplasia	Cranio-Lenticulo-Sutural Dysplasia, Clsd

Anemia, Congenital Dyserythropoietic, Type Ii

Congenital Dyserythropoietic Anemia Type Ii	CDAN2
Cda Ii	Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test
Cda Type Ii	Congenital Dyserythropoietic Anemia Type 2
Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test	Sec23b-Cdg
Congenital Dyserythropoietic Anemia, Type Ii	Dyserythropoietic Anemia, Hempas Type
Hempas	Cda Type 2
Dyserythropoietic Anemia, Congenital, Type Ii	Cda, Type Ii
Congenital Dyserythropoietic Anaemia Type 2	Congenital Dyserythropoietic Anaemia Type Ii
Anemia, Dyserythropoietic, Congenital Type 2	Hempas Anemia
Dyserythropoietic Anemia, Congenital Type 2	Anemia, Congenital Dyserythropoietic, 2
Dyserythropoietic Anemia Hempas Type	Anemia, Dyserythropoietic Congenital, Type Ii
Anemia, Dyserythropoietic, Congenital, Type Ii

Chylomicron Retention Disease

CMRD	Anderson Disease
Lipid Transport Defect Of Intestine	Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells
Andd	Anderson Syndrome
Crd	Andersons Disease
Malabsorption Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12605	SEC13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SEC13	VGNC	VGNC:77149
Felis catus	SEC13	VGNC	VGNC:64960
Bos taurus	SEC13	VGNC	VGNC:34403
Rattus norvegicus	SEC13	RGD	RGD:1359555
Canis familiaris	SEC13	VGNC	VGNC:45962
Mus musculus	SEC13	MGD	MGI:99832

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

关于 SEC13

功能概要

SEC13 基因产物(5)

SEC13 蛋白结构

SEC13 蛋白互作信息

关联疾病

直系同源

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SEC13 - SEC13 homolog, nuclear pore and COPII coat complex component Gene

关于 SEC13

功能概要

SEC13 基因产物(5)

SEC13 蛋白结构

SEC13 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

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T

X

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