1. Gene
  2. SEC16B - SEC16 homolog B, endoplasmic reticulum export factor Gene

SEC16B - SEC16 homolog B, endoplasmic reticulum export factor Gene

中文名称:SEC16 同系物 B,内质网输出因子

种属: Homo sapiens

同用名: RGPR; LZTR2; SEC16S; PGPR-p117; RGPR-p117

基因 ID: 89866 | 基因类型: protein coding

关于 SEC16B

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:177,928,788-177,984,284 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 1 paralogue. Broad expression in small intestine (RPKM 16.8), duodenum (RPKM 16.0) and 22 other tissues.

功能概要

SEC16B 是酿酒酵母 Sec16 的哺乳动物同系物,是组织过渡内质网 (ER) 位点和蛋白质输出所必需的 (Bhattacharyya 和 Glick,2007 [PubMed 17192411]) 。[OMIM 提供,2009 年 6 月]

SEC16B is a mammalian homolog of S. cerevisiae Sec16 that is required for organization of transitional endoplasmic reticulum (ER) sites and protein export (Bhattacharyya and Glick, 2007 [PubMed 17192411]).[supplied by OMIM, Jun 2009]

SEC16B 基因产物(5)

mRNA Protein Name
NM_001356499.2 NP_001343428.1 protein transport protein Sec16B isoform 2
NM_001390833.1 NP_001377762.1 protein transport protein Sec16B isoform 1
NM_001390834.1 NP_001377763.1 protein transport protein Sec16B isoform 4
NM_001390835.1 NP_001377764.1 protein transport protein Sec16B isoform 4
NM_033127.4 NP_149118.2 protein transport protein Sec16B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in endoplasmic reticulum organization IDA
IDA: 通过直接分析推断
21768384 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: 通过突变表型推断
21478858 GOA
involved in peroxisome fission IMP
IMP: 通过突变表型推断
21768384 GOA
involved in peroxisome organization IDA
IDA: 通过直接分析推断
21768384 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
21768384 GOA
involved in positive regulation of protein exit from endoplasmic reticulum IMP
IMP: 通过突变表型推断
21768384 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum exit site IDA
IDA: 通过直接分析推断
21478858 GOA
located in intracellular membrane-bounded organelle IDA
IDA: 通过直接分析推断
21768384 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SEC16B 蛋白结构

Sec16

Sec16: Vesicle coat trafficking protein Sec16 mid-region (278 - 378)

Sec16_C

Sec16_C: Sec23-binding domain of Sec16 (446 - 679)

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  • 1060 a.a.
蛋白主名 其他名称

protein transport protein Sec16B

leucine zipper transcription regulator 2

SEC16B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SEC16B Q96JE7 SEC13 Homo sapiens P55735
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus SEC16B VGNC VGNC:82505
Bos taurus SEC16B VGNC VGNC:34407
Rattus norvegicus SEC16B RGD RGD:621658
Canis familiaris SEC16B VGNC VGNC:45966
Macaca mulatta SEC16B VGNC VGNC:100136
Mus musculus SEC16B MGD MGI:2148802