2. Gene
  3. RNF41 - ring finger protein 41 Gene

RNF41 - ring finger protein 41 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 41

种属: Homo sapiens

同用名: FLRF; NRDP1; SBBI03

基因 ID: 10193 | 基因类型: protein coding

关于 RNF41

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:56,202,179-56,221,969 (from NCBI)

This gene has 12 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 10.6), prostate (RPKM 9.7) and 25 other tissues.

功能概要

该基因编码 E3 泛素连接酶。编码的蛋白质通过控制 JAK2 相关细胞因子受体降解和胞外域脱落之间的平衡，在 1 型细胞因子受体信号传导中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 6 月]

This gene encodes an E3 ubiquitin Ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

RNF41 基因产物(4)

mRNA Protein Name
NM_001242826.2 NP_001229755.1 E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_005785.4 NP_005776.1 E3 ubiquitin-protein ligase NRDP1 isoform 1
NM_194358.3 NP_919339.1 E3 ubiquitin-protein ligase NRDP1 isoform 2
NM_194359.2 NP_919340.1 E3 ubiquitin-protein ligase NRDP1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22493164 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11867753 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
27353365 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
27353365 GOA
enables small GTPase binding IPI
IPI: 通过物理相互作用推断
24056301 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
18541373 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
14765125 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
14765125 GOA
acts upstream of or within negative regulation of cell migration IMP
IMP: 通过突变表型推断
17145873 GOA
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
17145873 GOA
involved in positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
27353365 GOA
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
18541373 GOA
involved in proteasomal protein catabolic process IDA
IDA: 通过直接分析推断
18541373 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
24105792 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
14765125 GOA
acts upstream of or within regulation of MAPK cascade IDA
IDA: 通过直接分析推断
17145873 GOA
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
17145873 GOA
involved in regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
18541373 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum tubular network IDA
IDA: 通过直接分析推断
27353365 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
27353365 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF41 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 54)

USP8_interact

USP8_interact: USP8 interacting (137 - 315)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase NRDP1

RING-type E3 ubiquitin transferase NRDP1

RNF41 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNF41 Q9H4P4 ARL6IP4 Homo sapiens Q66PJ3-3
Y2H Array
25416956
Intra RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Array
25416956
Intra RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Array
32296183
Intra RNF41 Q9H4P4 ISCA2 Homo sapiens Q86U28
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra RNF41 Q9H4P4 HOMER2 Homo sapiens Q9NSB8
Y2H Array
25416956
Intra RNF41 Q9H4P4 ASB6 Homo sapiens Q9NWX5
Validated Y2H
32296183
Intra RNF41 Q9H4P4 ASB6 Homo sapiens Q9NWX5
Y2H Array
25416956
Intra RNF41 Q9H4P4 TTC1 Homo sapiens Q99614
Validated Y2H
25416956
Intra RNF41 Q9H4P4 TTC1 Homo sapiens Q99614
Y2H Array
25416956
Intra RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Y2H Array
32296183
Intra RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Anti Tag CoIP
26496610
Intra RNF41 Q9H4P4 N4BP3 Homo sapiens O15049
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Array
25416956
Intra RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Anti Tag CoIP
33961781
Intra RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra RNF41 Q9H4P4 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra RNF41 Q9H4P4 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra RNF41 Q9H4P4 RFC4 Homo sapiens P35249
Y2H Array
25416956
Intra RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Y2H Array
32296183
Intra RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 ENOPH1 Homo sapiens Q9UHY7
Validated Y2H
32296183
Intra RNF41 Q9H4P4 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Y2H Array
25416956
Intra RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Validated Y2H
25416956
Intra RNF41 Q9H4P4 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Y2H Prey Pooling
32296183
Intra RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Anti Tag CoIP
33961781
Intra RNF41 Q9H4P4 SRR Homo sapiens Q9GZT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12092 RNF41 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNF41 MGD MGI:1914838
Canis familiaris RNF41 VGNC VGNC:45670
Bos taurus RNF41 VGNC VGNC:34067
Rattus norvegicus RNF41 RGD RGD:1309557
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