2. Gene
  3. RFC4 - replication factor C subunit 4 Gene

RFC4 - replication factor C subunit 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：复制因子 C 亚基 4

种属: Homo sapiens

同用名: A1; RFC37

基因 ID: 5984 | 基因类型: protein coding

关于 RFC4

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,789,900-186,806,482 (from NCBI)

This gene has 13 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 108.6), ovary (RPKM 88.0) and 25 other tissues.

功能概要

DNA 聚合酶 delta 和 DNA 聚合酶 epsilon 对引物 DNA 模板的延伸需要辅助蛋白增殖细胞核抗原 (PCNA) 和复制因子 C (RFC) 。 RFC，也称为激活剂 1，是一种蛋白质复合物，由五个不同的亚基组成，分别为 140、40、38、37 和 36 kD。该基因编码 37 kD 亚基。该亚基与 36 和 40 kDa 亚基形成核心复合体。核心复合物具有 DNA 依赖性 ATP 酶活性，发现其在体外系统中受到 PCNA 的刺激。已经报道了编码相同蛋白质的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The elongation of primed DNA templates by DNA Polymerase delta and DNA Polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

RFC4 基因产物(2)

mRNA Protein Name
NM_002916.5 NP_002907.1 replication factor C subunit 4
NM_181573.3 NP_853551.1 replication factor C subunit 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to DNA clamp loader activity IDA
IDA: 通过直接分析推断
12930902 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9488738 GOA
contributes to single-stranded DNA helicase activity IDA
IDA: 通过直接分析推断
12930902 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA-templated DNA replication IDA
IDA: 通过直接分析推断
9488738 GOA
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: 通过直接分析推断
12930902 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Ctf18 RFC-like complex IDA
IDA: 通过直接分析推断
12930902 GOA
part of DNA replication factor C complex IDA
IDA: 通过直接分析推断
9488738 GOA
part of DNA replication factor C complex IPI
IPI: 通过物理相互作用推断
9488738 GOA
part of Elg1 RFC-like complex IDA
IDA: 通过直接分析推断
23277426 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RFC4 蛋白结构

AAA

AAA: ATPase family associated with various cellular activities (AAA) (74 - 200)

Rep_fac_C

Rep_fac_C: Replication factor C C-terminal domain (268 - 354)

  • 0
  • 100
  • 200
  • 300
  • 363 a.a.
蛋白主名 其他名称

replication factor C subunit 4

A1 37 kDa subunit

RFC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RFC4 P35249 RFC3 Homo sapiens P40938
Pull Down
9488738
Intra RFC4 P35249 RFC3 Homo sapiens P40938
Anti Tag CoIP
33961781
Intra RFC4 P35249 RFC3 Homo sapiens P40938
Anti Tag CoIP
28514442
Intra RFC4 P35249 RFC3 Homo sapiens P40938
Validated Y2H
32296183
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H
21516116
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
25416956
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Validated Y2H
25416956
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra RFC4 P35249 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra RFC4 P35249 RFC2 Homo sapiens P35250
Anti Tag CoIP
33961781
Intra RFC4 P35249 RFC2 Homo sapiens P35250
Pull Down
9488738
Intra RFC4 P35249 RFC2 Homo sapiens P35250
Pull Down
15655353
Intra RFC4 P35249 RFC2 Homo sapiens P35250
CoIP
15655353
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Anti Tag CoIP
33961781
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Crosslink
30021884
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
29892012
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Pooling
16189514
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Pull Down
9488738
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Validated Y2H
32296183
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
31515488
Intra RFC4 P35249 RFC5 Homo sapiens P40937
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11868 RFC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RFC4 RGD RGD:1310142
Mus musculus RFC4 MGD MGI:2146571
Macaca mulatta RFC4 VGNC VGNC:76903
Felis catus RFC4 VGNC VGNC:69297
Canis familiaris RFC4 VGNC VGNC:45495
Bos taurus RFC4 VGNC VGNC:33888
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