RFC5 - replication factor C subunit 5 Gene

中文名称：复制因子 C 亚基 5

种属: Homo sapiens

同用名: RFC36

关于 RFC5

功能概要

该基因编码复制因子 C 复合体的最小亚基，它由五个不同的亚基 (140、40、38、37 和 36 kDa) 组成，是 DNA 复制所必需的。该亚基与增殖细胞核抗原的 C 末端区域相互作用，需要在 S 期打开增殖细胞核抗原并将其加载到 DNA 上。它是 AAA+ (与各种细胞活动相关的 ATP 酶) ATP 酶家族的成员，并与具有 DNA 依赖性 ATP 酶活性的 38 和 40 kDa 亚基形成核心复合物。已在 9 号染色体上鉴定出一个相关的假基因。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 11 月]

This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]