2. Gene
  3. XAF1 - XIAP associated factor 1 Gene

XAF1 - XIAP associated factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：XIAP 相关因子 1

种属: Homo sapiens

同用名: BIRC4BP; XIAPAF1; HSXIAPAF1

基因 ID: 54739 | 基因类型: protein coding

关于 XAF1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,755,447-6,775,647 (from NCBI)

This gene has 19 transcripts (splice variants), 166 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 13.4), lung (RPKM 8.3) and 24 other tissues.

功能概要

该基因编码一种蛋白质，该蛋白质结合并抵消 IAP (细胞凋亡抑制剂) 蛋白质家族成员的抑制作用。 IAP 蛋白结合并抑制在细胞凋亡过程中激活的半胱天冬酶。 IAPs 和干扰其活性的蛋白质的比例，如编码的蛋白质，影响细胞凋亡信号通路的进展。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of Apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during Apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the Apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

XAF1 基因产物(9)

mRNA Protein Name
NM_001353134.2 NP_001340063.1 XIAP-associated factor 1 isoform 3
NM_001353135.1 NP_001340064.1 XIAP-associated factor 1 isoform 1
NM_001353136.2 NP_001340065.1 XIAP-associated factor 1 isoform 4
NM_001353137.2 NP_001340066.1 XIAP-associated factor 1 isoform 5
NM_001353138.2 NP_001340067.1 XIAP-associated factor 1 isoform 5
NM_001353139.2 NP_001340068.1 XIAP-associated factor 1 isoform 6
NM_001353140.2 NP_001340069.1 XIAP-associated factor 1 isoform 7
NM_017523.5 NP_059993.2 XIAP-associated factor 1 isoform 1
NM_199139.4 NP_954590.1 XIAP-associated factor 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular sequestering activity IDA
IDA: 通过直接分析推断
36394357 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of type I interferon production IDA
IDA: 通过直接分析推断
36394357 GOA
involved in response to interferon-beta IDA
IDA: 通过直接分析推断
18035482 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

XAF1 蛋白结构

zf-TRAF

zf-TRAF: TRAF-type zinc finger (55 - 101)

  • 0
  • 100
  • 200
  • 301 a.a.
蛋白主名 其他名称

XIAP-associated factor 1

BIRC4-binding protein

XAF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra XAF1 Q6GPH4 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra XAF1 Q6GPH4 RNF166 Homo sapiens Q96A37
Validated Y2H
32296183
Intra XAF1 Q6GPH4 RNF166 Homo sapiens Q96A37
Y2H Array
32296183
Intra XAF1 Q6GPH4 RNF166 Homo sapiens Q96A37
Anti Tag CoIP
33961781
Intra XAF1 Q6GPH4 RNF166 Homo sapiens Q96A37
Y2H Prey Pooling
32296183
Intra XAF1 Q6GPH4 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra XAF1 Q6GPH4 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra XAF1 Q6GPH4 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra XAF1 Q6GPH4 AKT1 Homo sapiens P31749
Anti Tag CoIP
33961781
Intra XAF1 Q6GPH4 VCP Homo sapiens P55072
Y2H Array
32296183
Intra XAF1 Q6GPH4 VCP Homo sapiens P55072
Y2H Prey Pooling
32296183
Intra XAF1 Q6GPH4 GLS2 Homo sapiens Q9UI32
Validated Y2H
32296183
Intra XAF1 Q6GPH4 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
32296183
Intra XAF1 Q6GPH4 BIRC7 Homo sapiens Q96CA5
Validated Y2H
32296183
Intra XAF1 Q6GPH4 BIRC7 Homo sapiens Q96CA5
Y2H Array
32296183
Intra XAF1 Q6GPH4 LRSAM1 Homo sapiens Q6UWE0
Validated Y2H
32296183
Intra XAF1 Q6GPH4 RNF114 Homo sapiens Q9Y508
Anti Tag CoIP
33961781
Intra XAF1 Q6GPH4 RNF114 Homo sapiens Q9Y508
Validated Y2H
32296183
Intra XAF1 Q6GPH4 RNF114 Homo sapiens Q9Y508
Y2H Array
32296183
Intra XAF1 Q6GPH4 RNF114 Homo sapiens Q9Y508
Y2H Prey Pooling
32296183
Intra XAF1 Q6GPH4 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 37

CTRCT37

Cca5

Cataract, Congenital, Cerulean Type, 5

Cataract 37, Autosomal Dominant

Congenital Cataract Cerulean Type 5
Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix
Alacrima, Achalasia, And Mental Retardation Syndrome

AAMR

Alacrima, Achalasia, And Intellectual Disability Syndrome

Alacrima, Achalasia, And Impaired Intellectual Development Syndrome

Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15864 XAF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus XAF1 MGD MGI:3772572
Macaca mulatta XAF1 VGNC VGNC:99332
Bos taurus XAF1 VGNC VGNC:36982
Canis familiaris XAF1 VGNC VGNC:48446
Rattus norvegicus XAF1 RGD RGD:1585988
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