1. Gene
  2. RNF114 - ring finger protein 114 Gene

RNF114 - ring finger protein 114 Gene

中文名称:无名指蛋白 114

种属: Homo sapiens

同用名: ZNF313; PSORS12

基因 ID: 55905 | 基因类型: protein coding

关于 RNF114

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,936,397-49,953,885 (from NCBI)

This gene has 8 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 40.7), spleen (RPKM 29.3) and 25 other tissues.

功能概要

预测可启用泛素蛋白连接酶活性。预计参与蛋白质多聚泛素化和泛素依赖性蛋白质分解代谢过程。位于胞质溶胶和质膜中。男性不育的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022]

RNF114 基因产物(1)

mRNA Protein Name
NM_018683.4 NP_061153.1 E3 ubiquitin-protein ligase RNF114
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19549727 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNF114 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (29 - 67)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (140 - 200)

  • 0
  • 100
  • 200
  • 228 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF114

RING-type E3 ubiquitin transferase RNF114

RNF114 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNF114 Q9Y508 YWHAG Homo sapiens P61981
Validated Y2H
32814053
Intra RNF114 Q9Y508 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
Intra RNF114 Q9Y508 YWHAG Homo sapiens P61981
Y2H Array
32814053
Intra RNF114 Q9Y508 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra RNF114 Q9Y508 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra RNF114 Q9Y508 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra RNF114 Q9Y508 UBE2D1 Homo sapiens P51668
Y2H Array
19549727
Intra RNF114 Q9Y508 UBE2D1 Homo sapiens P51668
Y2H
19549727
Intra RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
Intra RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
Intra RNF114 Q9Y508 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Psoriasis 12

PSORS12

Psoriasis Susceptibility 12

Psoriasis 12, Susceptibility To

Miliaria Crystallina
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RNF114 VGNC VGNC:45623
Macaca mulatta RNF114 VGNC VGNC:76725
Felis catus RNF114 VGNC VGNC:64665
Rattus norvegicus RNF114 RGD RGD:1303139
Mus musculus RNF114 MGD MGI:1933159
Bos taurus RNF114 VGNC VGNC:34012
Others RNF114 NCBI