TRIM38 - tripartite motif containing 38 Gene

中文名称：含三方基序 38

种属: Homo sapiens

同用名: RNF15; RORET

基因 ID: 10475 | 基因类型: protein coding

关于 TRIM38

This gene has 1 transcript (splice variant), 103 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 9.0), lymph node (RPKM 8.4) and 24 other tissues.

功能概要

该基因编码三联基序 (TRIM) 家族的成员。编码的蛋白包含一个 RING 型锌指、B 盒型锌指和 SPRY 结构域。这种蛋白质的功能尚未确定。该基因的假基因位于 4 号染色体的长臂上。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

TRIM38 基因产物(1)

mRNA	Protein	Name
NM_006355.5	NP_006346.1	E3 ubiquitin-protein ligase TRIM38

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	23275563	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	23077300	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: 通过直接分析推断	23077300	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: 通过直接分析推断	18248090	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRIM38 蛋白结构

zf-C3HC4_4

zf-B_box

PRY

SPRY

0
100
200
300
400
465 a.a.

蛋白主名

其他名称

E3 ubiquitin-protein ligase TRIM38

RING-type E3 ubiquitin transferase TRIM38

TRIM38 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRIM38	O00635	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
种属内	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
种属内	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
种属内	TRIM38	O00635	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
种属内	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Validated Y2H	25416956
种属内	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Array	25416956
种属内	TRIM38	O00635	GC20	Homo sapiens	Q6FG85	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	MTURN	Homo sapiens	Q8N3F0	Validated Y2H	32296183
种属内	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Array	32296183
种属内	TRIM38	O00635	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
种属内	TRIM38	O00635	RNF4	Homo sapiens	P78317	Validated Y2H	32296183
种属内	TRIM38	O00635	TSPYL4	Homo sapiens	Q9UJ04	Validated Y2H	32296183
种属内	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Validated Y2H	32296183
种属内	TRIM38	O00635	HSPA8	Homo sapiens	P11142	Y2H Array	25416956
种属内	TRIM38	O00635	HSPA1L	Homo sapiens	P34931	Validated Y2H	32296183
种属内	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Validated Y2H	25416956
种属内	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Array	31515488
种属内	TRIM38	O00635	HSPA2	Homo sapiens	P54652	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
种属内	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Y2H Array	32296183
种属内	TRIM38	O00635	PSMA4	Homo sapiens	P25789	Validated Y2H	32296183
种属内	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Prey Pooling	32296183
种属内	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Validated Y2H	32296183
种属内	TRIM38	O00635	PIAS4	Homo sapiens	Q8N2W9	Y2H Array	32296183
种属内	TRIM38	O00635	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	25416956
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Validated Y2H	32296183
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	25416956
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	29892012
种属内	TRIM38	O00635	RFC5	Homo sapiens	P40937	Y2H Array	31515488
种属内	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
种属内	TRIM38	O00635	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
种属内	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
种属内	TRIM38	O00635	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	TRIM38	O00635	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
种属内	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
种属内	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
种属内	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
种属内	TRIM38	O00635	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
种属内	TRIM38	O00635	STXBP1	Homo sapiens	P61764	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Fanconi Renotubular Syndrome 2

FRTS2

Fanconi Renotubular Syndrome, Type 2

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic	Acute Myeloblastic Leukemia Type 3
Aml M3	APL
Leukemia, Acute Promyelocytic, Somatic	Aml With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Apml
Acute Myeloblastic Leukemia 3	Acute Myeloid Leukemia With T(15
17)(Q22	Q12)
(Pml/Raralpha) And Variants	Acute Myeloblastic Leukaemia Type 3
Acute Myeloid Leukaemia M3	Acute Myeloid Leukemia M3
Acute Promyelocytic Leukaemia	M3 Anll
Myeloid Leukemia, Acute, M3	Leukemia Promyelocytic Acute
Leukemia, Promyelocytic, Acute	Leukemia, Acute, Promyelocytic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15042	TRIM38 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	TRIM38	VGNC	VGNC:78548
Bos taurus	TRIM38	VGNC	VGNC:36333
Rattus norvegicus	TRIM38	RGD	RGD:1596868
Canis familiaris	TRIM38	VGNC	VGNC:47819
Felis catus	TRIM38	VGNC	VGNC:66537
Mus musculus	TRIM38	MGD	MGI:2684869

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