2. Gene
  3. HSPA1L - heat shock protein family A (Hsp70) member 1 like Gene

HSPA1L - heat shock protein family A (Hsp70) member 1 like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 A (Hsp70) 成员 1 样

种属: Homo sapiens

同用名: HSP70T; hum70t; HSP70-1L; HSP70-HOM

基因 ID: 3305 | 基因类型: protein coding

关于 HSPA1L

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,809,619-31,815,283 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 110 orthologues and 13 paralogues. Biased expression in testis (RPKM 35.8) and ovary (RPKM 2.3).

功能概要

该基因编码一个 70kDa 的热休克蛋白。与其他热休克蛋白一起，该蛋白稳定现有蛋白以防止聚集，并介导新翻译蛋白在胞质溶胶和细胞器中的折叠。该基因位于主要组织相容性复合体 III 类区域，与两个密切相关的基因簇在一起，这两个基因也编码 70kDa 热休克蛋白的亚型。[RefSeq 提供，2008 年 7 月]

This gene encodes a 70kDa heat shock protein. In conjunction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

HSPA1L 基因产物(1)

mRNA Protein Name
NM_005527.4 NP_005518.3 heat shock 70 kDa protein 1-like
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
17182002 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25036637 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
24270810 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
21231916 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of protein targeting to mitochondrion IMP
IMP: 通过突变表型推断
24270810 GOA
involved in protein refolding IDA
IDA: 通过直接分析推断
21231916 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21231916 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPA1L 蛋白结构

HSP70

HSP70: Hsp70 protein (8 - 614)

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  • 641 a.a.
蛋白主名 其他名称

heat shock 70 kDa protein 1-like

epididymis secretory sperm binding protein

HSPA1L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSPA1L P34931 TRIM38 Homo sapiens O00635
Y2H Prey Pooling
32296183
种属内
HSPA1L P34931 TRIM38 Homo sapiens O00635
Y2H Array
32296183
种属内
HSPA1L P34931 BAG4 Homo sapiens O95429
Y2H Array
32296183
种属内
HSPA1L P34931 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Uveoparotid Fever

Heerfordt'S Syndrome
Anthracosis

Black Lung

Coal Workers' Pneumoconiosis

Melanoedema

Black Lung Disease

Pneumoconiosis

Coal Miner'S Pneumoconiosis

Coal Workers' Lung

Coal Worker'S Pneumoconiosis

Coal Workers Pneumoconiosis

Coal Miners' Lung

Coal Miners' Pneumoconiosis

Coal Pneumoconiosis

Colliers' Anthracosis

Colliers' Lung

Lung Melanosis

Miners' Asthma

Miners' Lung

Pneumomelanosis

Cwp - [Coalworkers Pneumoconiosis]

Fibrosis Of Lung With Anthracosilicosis

Lung Fibrosis With Anthracosis

Miners' Pneumoconiosis

Carbon Lung

Coalworker Lung

Collier'S Asthma

Anthracosilicosis

Lung Anthracosis
Visceral Leishmaniasis

Kala-Azar

Leishmaniasis, Visceral

Infection By Visceral Leishmaniasis

Leishmaniasis Visceral

Sahib Disease

Ponos

Burdwan Fever

Mard El Bicha

Sirkari Disease

Indian Visceral Leishmaniasis

Dumdum Fever

Visceral Leishmaniasis Due To Leishmania Donovani
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06426 HSPA1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HSPA1L RGD RGD:1595925
Mus musculus HSPA1L MGD MGI:96231
Macaca mulatta HSPA1L VGNC VGNC:81079
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