RFC3 - replication factor C subunit 3 Gene

中文名称：复制因子 C 亚基 3

种属: Homo sapiens

同用名: RFC38

关于 RFC3

功能概要

DNA 聚合酶 delta 和 DNA 聚合酶 epsilon 对引物 DNA 模板的延伸需要辅助蛋白增殖细胞核抗原 (PCNA) 和复制因子 C (RFC) 。 RFC，也称为激活剂 1，是一种蛋白质复合物，由五个不同的亚基组成，分别为 140、40、38、37 和 36 kDa。该基因编码 38 kDa 亚基。该亚基对于 140 kDa 亚基与由 36、37 和 40 kDa 亚基组成的核心复合体之间的相互作用至关重要。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The elongation of primed DNA templates by DNA Polymerase delta and DNA Polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]