2. Gene
  3. SRR - serine racemase Gene

SRR - serine racemase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝氨酸消旋酶

种属: Homo sapiens

同用名: ILV1; ISO1

基因 ID: 63826 | 基因类型: protein coding

关于 SRR

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:2,303,378-2,325,264 (from NCBI)

This gene has 8 transcripts (splice variants), 121 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 6.5), testis (RPKM 6.3) and 25 other tissues.

功能概要

启用多种功能，包括 L-丝氨酸解氨酶活性； PDZ 域绑定活动；和阴离子结合活性。参与丙酮酸生物合成过程；对脂多糖的反应；和丝氨酸家族氨基酸代谢过程。位于细胞质和神经细胞体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including L-serine ammonia-lyase activity; PDZ domain binding activity; and anion binding activity. Involved in pyruvate biosynthetic process; response to lipopolysaccharide; and serine family amino acid metabolic process. Located in cytoplasm and neuronal cell body. [provided by Alliance of Genome Resources, Apr 2022]

SRR 基因产物(2)

mRNA Protein Name
NM_001304803.1 NP_001291732.1 serine racemase isoform b
NM_021947.3 NP_068766.1 serine racemase isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
20106978 GOA
enables L-serine ammonia-lyase activity IDA
IDA: 通过直接分析推断
18812225 GOA
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
16314870 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15681805 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
20106978 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
20106978 GOA
enables pyridoxal phosphate binding IDA
IDA: 通过直接分析推断
20106978 GOA
enables serine racemase activity IDA
IDA: 通过直接分析推断
11054547 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-serine biosynthetic process IDA
IDA: 通过直接分析推断
11054547 GOA
involved in D-serine metabolic process IDA
IDA: 通过直接分析推断
20106978 GOA
involved in L-serine metabolic process IDA
IDA: 通过直接分析推断
11054547 GOA
involved in pyruvate biosynthetic process IDA
IDA: 通过直接分析推断
18812225 GOA
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
15681805 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16314870 GOA
located in neuronal cell body IDA
IDA: 通过直接分析推断
17880399 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRR 蛋白结构

PALP

PALP: Pyridoxal-phosphate dependent enzyme (21 - 314)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
蛋白主名 其他名称

serine racemase

D-serine ammonia-lyase

SRR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Array
32296183
Intra SRR Q9GZT4 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
32296183
Intra SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Prey Pooling
32296183
Intra SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Validated Y2H
32296183
Intra SRR Q9GZT4 SRR Homo sapiens Q9GZT4
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 24

Severe Combined Immunodeficiency Due To Ctps1 Deficiency

IMD24

Scid Due To Ctps1 Deficiency

Immunodeficiency, Type 24
Serine Deficiency
Glanders

Farcy Pipes

Infection Due To Pseudomonas Mallei

Burkholderia Mallei

Burkholderia Mallei Infection

Equina

Equine Glanders

Farcy

Farcy Buds

Farcy Cords

Infection Due To Actinobacillus Mallei

Infection Due To Malleomyces Mallei

Maliasmus

Malleus

Farce

Actinobacillosis

Actinobacillus Infection
Subacute Bacterial Endocarditis

Endocarditis Lenta

Sbe - Subacute Bacterial Endocarditis

Subacute Endocarditis, Lenta

Endocarditis, Subacute Bacterial
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Syndromic X-Linked Intellectual Disability Snyder Type

Snyder-Robinson Syndrome

Mental Retardation, X-Linked, Snyder-Robinson Type

Spermine Synthase Deficiency

Srs

Snyder-Robinson Mental Retardation Syndrome

X-Linked Intellectual Disability Snyder-Robinson Type

Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type

Snyder-Robinson X-Linked Mental Retardation Syndrome
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13784 SRR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SRR RGD RGD:735094
Felis catus SRR VGNC VGNC:65689
Bos taurus SRR VGNC VGNC:35292
Mus musculus SRR MGD MGI:1351636
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