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  4. Cadmium pyrithione

Cadmium pyrithione是一种金属化合物，具有抑制蛋白质去泛素酶活性。Cadmium pyrithione处理导致癌细胞和原代白血病细胞中泛素化蛋白质的显著积累。Cadmium pyrithione强效抑制了蛋白酶体去泛素酶（如USP14和UCHL5）的活性，但对20S蛋白酶体活性的抑制作用较小。Cadmium pyrithione的抗癌活性与通过半胱天冬酶激活诱导细胞凋亡有关。此外，Cadmium pyrithione抑制抑制了蛋白酶体功能，并在动物异种移植模型中抑制肿瘤生长。

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Cadmium pyrithione Chemical Structure

Cadmium pyrithione Chemical Structure

CAS No. : 18897-36-4

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Cadmium pyrithione 相关抗体

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  • 生物活性

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生物活性

Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models[1].

分子量

364.72

Formula

C10H8CdN2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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Cadmium pyrithione 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Cadmium pyrithione18897-36-4OthersInhibitorinhibitorinhibit

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