2. Gene
  3. ARHGAP22 - Rho GTPase activating protein 22 Gene

ARHGAP22 - Rho GTPase activating protein 22 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 22

种属: Homo sapiens

同用名: RhoGAP2; RhoGap22

基因 ID: 58504 | 基因类型: protein coding

关于 ARHGAP22

Cytogenetic location: 10q11.22-q11.23 Genomic coordinates (GRCh38): 10:48,429,831-48,656,265 (from NCBI)

This gene has 15 transcripts (splice variants), 122 orthologues and 2 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码 GTPase 激活蛋白家族的一个成员，该家族激活属于小 GTP 结合蛋白 Ras 超家族的 GTPase。编码的蛋白质是胰岛素反应性的，依赖于激酶 Akt，并且需要依赖于 Akt 的 14-3-3 结合蛋白，后者依次与两个丝氨酸残基结合。这些相互作用的结果是细胞运动的调节。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the Ras superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ARHGAP22 基因产物(8)

mRNA Protein Name
NM_001256024.2 NP_001242953.1 rho GTPase-activating protein 22 isoform 1
NM_001256025.3 NP_001242954.1 rho GTPase-activating protein 22 isoform 2
NM_001256026.2 NP_001242955.1 rho GTPase-activating protein 22 isoform 4
NM_001347735.2 NP_001334664.1 rho GTPase-activating protein 22 isoform 7
NM_001347736.2 NP_001334665.1 rho GTPase-activating protein 22 isoform 8
NM_001347737.2 NP_001334666.1 rho GTPase-activating protein 22 isoform 9
NM_001347738.2 NP_001334667.1 rho GTPase-activating protein 22 isoform 2
NM_021226.4 NP_067049.2 rho GTPase-activating protein 22 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21078624 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
21926414 GOA
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
21926414 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21926414 GOA
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
21926414 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP22 蛋白结构

PH

PH: PH domain (39 - 143)

RhoGAP

RhoGAP: RhoGAP domain (173 - 321)

  • 0
  • 200
  • 400
  • 600
  • 698 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 22

rho-type GTPase-activating protein 22

ARHGAP22 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARHGAP22 Q7Z5H3 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Conduct Disorder
Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia

CMS6

Cmsea

Congenital Myasthenic Syndrome 6

Familial Infantile Myasthenia Gravis 2

Fimg2

Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea

Congenital Myasthenic Syndrome Type Ia2, Formerly

Cms1a2, Formerly

Cms Ia2, Formerly

Myasthenia, Familial Infantile, Formerly

Fim, Formerly

Myasthenia Gravis, Familial Infantile, 2, Formerly

Fimg2, Formerly

Cms Ia2

Cms1a2

Congenital Myasthenic Syndrome 6, Presynaptic

Congenital Myasthenic Syndrome Type Ia2

Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea

Fim

Cms1a

Cms-Ea

Cms Ia

Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea

Congenital Myasthenic Syndrome Type 1a

Congenital Myasthenic Syndrome Type Ia

Myasthenic Syndrome, Congenital, Type 6, Presynaptic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00922 ARHGAP22 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ARHGAP22 RGD RGD:1307237
Canis familiaris ARHGAP22 VGNC VGNC:52984
Mus musculus ARHGAP22 MGD MGI:2443418
Bos taurus ARHGAP22 VGNC VGNC:26081
Macaca mulatta ARHGAP22 VGNC VGNC:69931
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