ID2 - inhibitor of DNA binding 2 Gene

中文名称：DNA 结合抑制因子 2

种属: Homo sapiens

同用名: GIG8; ID2A; ID2H; bHLHb26

基因 ID: 3398 | 基因类型: protein coding

关于 ID2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:8,682,056-8,684,461 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues.

功能概要

该基因编码的蛋白属于 DNA 结合抑制剂家族，成员为转录调节因子，含有螺旋-环-螺旋 (HLH) 结构域，不含碱性结构域。 DNA 结合抑制剂家族的成员通过 HLH 结构域抑制它们的异二聚化伙伴，以显性负性方式抑制基本螺旋-环-螺旋转录因子的功能。这种蛋白质可能在负向调节细胞分化中发挥作用。该基因的假基因位于 3 号染色体上。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

ID2 基因产物(1)

mRNA	Protein	Name
NM_002166.5	NP_002157.2	DNA-binding protein inhibitor ID-2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10915743	GOA
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	16311606	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	14627819	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	14627819	GOA
acts upstream of regulation of G1/S transition of mitotic cell cycle	IMP IMP: 通过突变表型推断	16311606	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	16311606	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with cytoplasm	IDA IDA: 通过直接分析推断	16311606	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	20861012	GOA
located in cytosol	IDA IDA: 通过直接分析推断	16311606	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16311606	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ID2 蛋白结构

HLH

0
100
134 a.a.

蛋白主名

其他名称

DNA-binding protein inhibitor ID-2

DNA-binding protein inhibitor ID2

ID2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ID2	Q02363	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32296183
种属内	ID2	Q02363	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
种属内	ID2	Q02363	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
种属内	ID2	Q02363	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
种属内	ID2	Q02363	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
种属内	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Validated Y2H	32814053
种属内	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Y2H Array	32814053
种属内	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Y2H Pooling	32814053
种属内	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
种属内	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
种属内	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
种属内	ID2	Q02363	PPIB	Homo sapiens	P23284	Y2H Array	32814053
种属内	ID2	Q02363	PPIB	Homo sapiens	P23284	Y2H Pooling	32814053
种属内	ID2	Q02363	PPIB	Homo sapiens	P23284	Validated Y2H	32814053
种属内	ID2	Q02363	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
种属内	ID2	Q02363	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
种属内	ID2	Q02363	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
种属内	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
种属内	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
种属内	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
种属内	ID2	Q02363	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
种属内	ID2	Q02363	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
种属内	ID2	Q02363	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
种属内	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	ID2	Q02363	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
种属内	ID2	Q02363	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
种属内	ID2	Q02363	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
种属内	ID2	Q02363	TCF4	Homo sapiens	P15884	Y2H	16549780
种属内	ID2	Q02363	TCF4	Homo sapiens	P15884	Anti Tag CoIP	33961781
种属内	ID2	Q02363	TCF4	Homo sapiens	P15884	Anti Tag CoIP	28514442
种属内	ID2	Q02363	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	33961781
种属内	ID2	Q02363	TCF12	Homo sapiens	Q99081	Anti Bait CoIP	19321746
种属内	ID2	Q02363	TCF12	Homo sapiens	Q99081	Y2H	16549780
种属内	ID2	Q02363	C22orf39	Homo sapiens	Q6P5X5	Validated Y2H	32296183
种属内	ID2	Q02363	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
种属内	ID2	Q02363	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
种属内	ID2	Q02363	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
种属内	ID2	Q02363	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	22453338
种属内	ID2	Q02363	PDLIM5	Homo sapiens	Q96HC4	Y2H	16549780
种属内	ID2	Q02363	TCF3	Homo sapiens	P15923	Anti Tag CoIP	33961781
种属内	ID2	Q02363	TCF3	Homo sapiens	P15923	Anti Bait CoIP	19321746
种属内	ID2	Q02363	TCF3	Homo sapiens	P15923-1	Y2H	10915743
种属内	ID2	Q02363	TCF3	Homo sapiens	P15923-1	Pull Down	10915743
种属内	ID2	Q02363	PKD2	Homo sapiens	Q13563	Confocal	16311606
种属内	ID2	Q02363	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
种属内	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
种属内	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
种属内	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
种属内	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
种属内	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
种属内	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Hydronephrosis

Stricture Of Ureteropelvic Junction With Hydronephrosis

Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1	Autosomal Dominant Non-Syndromic Intellectual Disability 1
Mental Retardation, Autosomal Dominant 1	Autosomal Dominant Intellectual Developmental Disorder 1

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-N4058	Helichrysetin	Inducer	99.92%	否
HY-144707	AK-778-XXMU	Inducer	98.82%	否
HY-155705	BMP agonist 1		/	否
HY-RS06523	ID2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-119966	CCT036477	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ID2	VGNC	VGNC:59229
Rattus norvegicus	ID2	RGD	RGD:2859
Macaca mulatta	ID2	VGNC	VGNC:97777
Felis catus	ID2	VGNC	VGNC:97461
Mus musculus	ID2	MGD	MGI:96397
Others	ID2	NCBI

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