2. TGF-beta/Smad Stem Cell/Wnt PI3K/Akt/mTOR
  3. TGF-β Receptor GSK-3 β-catenin
  4. BMP agonist 1

BMP agonist 1 (compound 2 b) 是骨形态发生蛋白 (BMP) 的小分子激动剂。BMP agonist 1 与 BMP 协同诱导 C2C12 细胞分化，且高度依赖于活性 BMP 信号传导。BMP agonist 1 抑制了 GSK3β，增加了 β-catenin 的信号表达，协同调节了 Id2 和 Id3 的表达。BMP agonist 1 可用于骨骼疾病和缺陷的研究。

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BMP agonist 1 Chemical Structure

BMP agonist 1 Chemical Structure

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BMP agonist 1 相关抗体

Top Publications Citing Use of Products

查看 TGF-β Receptor 亚型特异性产品:

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ALK1 ALK2 ALK3 ALK4 ALK5 ALK6 ALK7 TGFβR2 ACVR2A ACVR2B

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMP agonist 1 (compound 2 b) is a small-molecule agonist of bone morphogenic protein (BMP). BMP induces C2C12 cell differentiation with BMP and highly depends on active BMP signaling. BMP agonist 1 inhibits GSK3β, increases β-catenin signaling and synergistically regulates Id2and Id3 expression. BMP agonist 1 is used in diseases and defects of the skeleton research[1].

体外研究
(In Vitro)

BMP agonist 1 (0.01-10 μM，24 小时) 减少了 C2C12 细胞的增殖[1]。
BMP agonist 1 (0.5-1 μM，2 小时) 抑制了 C2C12 细胞中的 GSK3β，增加了 β-catenin 的信号表达，协同调节了 Id2 和 Id3 的表达[1]。
BMP agonist 1 (0.01-10 μM) 在与 Chromenone 1 (0.5−1 μM) 联用时，有效促进了 C2C12 细胞中典型BMP增强因子 Chromenone 1 (HY-143891) 的成骨分化 (Alp 活性)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BMP agonist 1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM
Incubation Time: 24, 72 h
Result: Differentiaed in C2C12 osteoblast at the low-dose BMP-4 (7.5 ng/mL).
Reduced the cell numbers and stopped the proliferation at higher concentrations.
Highly induced Id1 and Id3, elevated Runx2 levels.

Cell Differentiation Assay[1]

Cell Line: C2C12 cells
Concentration: 0.01-10 μM (in combination with (0.05, 0.2, 0.5, or 1 μM Chromenone 1)
Incubation Time:
Result: Highly overadditive effects and increased potency with Chromenone 1.
Reached the highest synergy scores (i.e., delta scores) at a concentration of 0.3 μM with 0.5−1 μM Chromenone 1.
分子量

392.36

Formula

C21H16N2O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMP agonist 1 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMP agonist 1BMP agonist1BMP agonist-1TGF-β ReceptorGSK-3β-cateninTransforming growth factor beta receptorsGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninC2C12BMPbone morphogenic proteinInhibitorinhibitorinhibit

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BMP agonist 1
目录号：
HY-155705
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