2. Gene
  3. RPL28 - ribosomal protein L28 Gene

RPL28 - ribosomal protein L28 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 L28

种属: Homo sapiens

同用名: L28

基因 ID: 6158 | 基因类型: protein coding

关于 RPL28

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,385,932-55,403,342 (from NCBI)

This gene has 11 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in spleen (RPKM 70.1), ovary (RPKM 68.3) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白属于核糖体蛋白 L28E 家族。它位于细胞质中。与邻近的正常组织相比，已观察到该基因在结直肠癌中的可变表达，尽管尚未发现表达水平与疾病严重程度之间的相关性。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 10 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L28E family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

RPL28 基因产物(6)

mRNA Protein Name
NM_000991.5 NP_000982.2 60S ribosomal protein L28 isoform 2
NM_001136134.1 NP_001129606.1 60S ribosomal protein L28 isoform 1
NM_001136135.2 NP_001129607.1 60S ribosomal protein L28 isoform 3
NM_001136136.1 NP_001129608.1 60S ribosomal protein L28 isoform 4
NM_001136137.1 NP_001129609.1 60S ribosomal protein L28 isoform 5
NM_001363697.1 NP_001350626.1 60S ribosomal protein L28 isoform 6
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20434207 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell body IDA
IDA: 通过直接分析推断
15121898 GOA
located in cytoplasmic ribonucleoprotein granule IDA
IDA: 通过直接分析推断
15121898 GOA
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
32669547 GOA
part of cytosolic large ribosomal subunit IPI
IPI: 通过物理相互作用推断
25901680 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
located in dendrite IDA
IDA: 通过直接分析推断
15121898 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL28 蛋白结构

Ribosomal_L28e

Ribosomal_L28e: Ribosomal L28e protein family (5 - 121)

  • 0
  • 100
  • 137 a.a.
蛋白主名 其他名称

60S ribosomal protein L28

large ribosomal subunit protein eL28

RPL28 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPL28 P46779 DCC Homo sapiens P43146
Density Sedimentation
20434207
Intra RPL28 P46779 RPL4 Homo sapiens P36578
Anti Tag CoIP
28514442
Intra RPL28 P46779 RPL4 Homo sapiens P36578
Crosslink
30021884
Intra RPL28 P46779 RPL4 Homo sapiens P36578
Anti Tag CoIP
33961781
Intra RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Intra RPL28 P46779 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
32296183
Intra RPL28 P46779 CCNDBP1 Homo sapiens O95273
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia 2

DBA2

Anemia, Diamond-Blackfan, 2

Anemia Diamond-Blackfan 2
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12182 RPL28 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPL28 MGD MGI:101839
Rattus norvegicus RPL28 RGD RGD:621193
Bos taurus RPL28 VGNC VGNC:34114
Canis familiaris RPL28 VGNC VGNC:45717
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