DDX5 - DEAD-box helicase 5 Gene

中文名称：死盒解旋酶 5

种属: Homo sapiens

同用名: p68; HLR1; G17P1; HUMP68

关于 DDX5

功能概要

该基因编码 RNA 解旋酶 DEAD 盒家族的成员，由于其作为衔接分子的作用，参与多种细胞过程，促进与大量其他因素的相互作用。这种蛋白质参与包括 RNA 结构改变在内的途径，作为转录的核心调节因子、剪接调节因子以及小的非编码 RNA 的加工发挥作用。这个家族的成员包含九个保守基序，包括保守的 Asp-Glu-Ala-Asp (DEAD) 基序，对 ATP 结合和水解以及 RNA 结合和解旋活动很重要。该基因的失调可能在癌症发展中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 9 月]

This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in Cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]