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  3. EXOSC10 - exosome component 10 Gene

EXOSC10 - exosome component 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外泌体组分 10

种属: Homo sapiens

同用名: p2; p3; p4; RRP6; PMSCL; Rrp6p; PM-Scl; PMSCL2; PM/Scl-100

基因 ID: 5394 | 基因类型: protein coding

关于 EXOSC10

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,066,618-11,099,869 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 18.4), testis (RPKM 18.0) and 25 other tissues.

功能概要

启用 3'-5'-核糖核酸外切酶活性。参与多个过程，包括 RNA 分解代谢过程； 5.8S rRNA 的成熟；以及通过端粒酶对端粒维持的负调节。位于胞质溶胶中；核腔;和转录活性染色质。核外泌体的一部分 (RNase 复合物) 。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA catabolic process; maturation of 5.8S rRNA; and negative regulation of telomere maintenance via Telomerase. Located in cytosol; nuclear lumen; and transcriptionally active chromatin. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC10 基因产物(2)

mRNA Protein Name
NM_001001998.3 NP_001001998.1 exosome component 10 isoform 1
NM_002685.4 NP_002676.1 exosome component 10 isoform 2

EXOSC10 蛋白结构

PMC2NT

PMC2NT: PMC2NT (NUC016) domain (43 - 133)

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (289 - 455)

HRDC

HRDC: HRDC domain (506 - 570)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 885 a.a.
蛋白主名 其他名称

exosome component 10

P100 polymyositis-scleroderma overlap syndrome-associated autoantigen

EXOSC10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EXOSC10 Q01780 DDX5 Homo sapiens P17844
Anti Bait CoIP
23143267
Intra EXOSC10 Q01780 EXOSC7 Homo sapiens Q15024
Anti Tag CoIP
11812149
Intra EXOSC10 Q01780 EXOSC5 Homo sapiens Q9NQT4
Anti Tag CoIP
11812149
Intra EXOSC10 Q01780 EXOSC8 Homo sapiens Q96B26
Y2H
15231747
Intra EXOSC10 Q01780 MPHOSPH6 Homo sapiens Q99547
Anti Bait CoIP
16396833
Intra EXOSC10 Q01780 DIS3 Homo sapiens Q9Y2L1
Y2H
15231747
Intra EXOSC10 Q01780 C1D Homo sapiens Q13901
Anti Bait CoIP
17412707
Intra EXOSC10 Q01780 C1D Homo sapiens Q13901
Pull Down
17412707
Intra EXOSC10 Q01780 C1D Homo sapiens Q13901
Confocal
17412707
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Polymyositis

Pm - [Polymyositis]
Systemic Scleroderma

Scleroderma

Progressive Systemic Sclerosis

Systemic Sclerosis

Scleroderma, Systemic

Scleroderma Syndrome

Dermatosclerosis

Familial Progressive Scleroderma

Progressive Scleroderma

Scleroderma Disease

Scleroderma, Localized

Diffuse Scleroderma

Scleroderma, Familial Progressive
Diffuse Scleroderma

Diffuse Systemic Sclerosis

Systemic Sclerosis, Diffuse

Scleroderma, Diffuse

Systemic Scleroderma

Progressive System Sclerosis
Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6

Autosomal Recessive Dyskeratosis Congenita 6

Dyskeratosis Congenita, Autosomal Recessive, 6

Dyskeratosis Congenita, Autosomal Recessive, Type 6
Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome
Facial Hemiatrophy

Parry-Romberg Syndrome
Dyskinesia Of Esophagus

Esophageal Motility Disorders

Dyskinesia Of Oesophagus

Esophageal Dysmotility

Esophageal Motility Disorder

Oesophageal Dysmotility

Oesophageal Motor Disorder

Esophageal Spasm
Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Nonspecific Interstitial Pneumonia

Nsip

Non-Specific Interstitial Pneumonia

Non-Specific Idiopathic Interstitial Pneumonia

Non-Specific Interstitial Pneumonia Nos
Immunodeficiency 25

Immunodeficiency Due To Defect In Cd3-Zeta

IMD25

Immunodeficiency, Type 25
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia

Lip Disease

Lip Diseases

LIP

Disease Of Lips
Localized Scleroderma

Morphea

Localised Scleroderma

Localized Fibrosing Scleroderma

Circumscribed Scleroderma

Localised Morphea

Localised Morphoea

Localized Morphea

Scleroderma, Circumscribed Or Localised

Scleroderma, Circumscribed Or Localized

Scleroderma, Localized
Crest Syndrome
Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave
Splenic Tuberculosis

Tuberculosis, Splenic
Telangiectasis

Telangiectasia
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome

Diffuse Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis

Ipf

Idiopathic Interstitial Pneumonias

Idiopathic Interstitial Pneumonia, Not Otherwise Specified

Pulmonary Fibrosis
Collagen Disease

Collagen Diseases

Collagen Disorder
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Muscle Tissue Disease
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome
Myopathy

Muscular Diseases

Myopathies
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04597 EXOSC10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus EXOSC10 VGNC VGNC:28656
Mus musculus EXOSC10 MGD MGI:1355322
Canis familiaris EXOSC10 VGNC VGNC:40522
Felis catus EXOSC10 VGNC VGNC:68926
Rattus norvegicus EXOSC10 RGD RGD:1593248
Macaca mulatta EXOSC10 VGNC VGNC:72478
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