1. Gene
  2. DIS3 - DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Gene

DIS3 - DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Gene

中文名称:DIS3 同源物、外泌体核糖核酸内切酶和 3'-5' 核糖核酸外切酶

种属: Homo sapiens

同用名: RRP44; dis3p; EXOSC11; KIAA1008; 2810028N01Rik

基因 ID: 22894 | 基因类型: protein coding

关于 DIS3

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,752,169-72,781,900 (from NCBI)

This gene has 5 transcripts (splice variants), 238 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 10.1), lymph node (RPKM 7.2) and 25 other tissues.

功能概要

启用 3'-5'-核糖核酸外切酶活性;核酸内切酶活性;和胍基核苷酸交换因子活性。参与 CUT 分解代谢过程和 rRNA 分解代谢过程。位于细胞质和核质中。核外泌体的一部分 (RNase 复合物) 。 [由基因组资源联盟提供,2022 年 4 月]

Enables 3'-5'-exoribonuclease activity; Endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

DIS3 基因产物(4)

mRNA Protein Name
NM_001128226.3 NP_001121698.1 exosome complex exonuclease RRP44 isoform b
NM_001322348.2 NP_001309277.1 exosome complex exonuclease RRP44 isoform c
NM_001322349.2 NP_001309278.1 exosome complex exonuclease RRP44 isoform d
NM_014953.5 NP_055768.3 exosome complex exonuclease RRP44 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5'-RNA exonuclease activity IMP
IMP: 通过突变表型推断
20531386 GOA
enables endonuclease activity IMP
IMP: 通过突变表型推断
20531386 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: 通过直接分析推断
9562621 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15231747 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CUT catabolic process IMP
IMP: 通过突变表型推断
19056938 GOA
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
17174896 GOA
involved in RNA processing IDA
IDA: 通过直接分析推断
17174896 GOA
involved in rRNA catabolic process IMP
IMP: 通过突变表型推断
20368444 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20531386 GOA
part of nuclear exosome (RNase complex) IDA
IDA: 通过直接分析推断
20531386 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
20531386 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
20531389 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20531386 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DIS3 蛋白结构

PIN_4

PIN_4: PIN domain (68 - 194)

RNB

RNB: RNB domain (467 - 792)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 958 a.a.
蛋白主名 其他名称

exosome complex exonuclease RRP44

DIS3 exosome endoribonuclease and 3'-5' exoribonuclease

DIS3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DIS3 Q9Y2L1 EXOSC2 Homo sapiens Q13868 20531386
种属内
DIS3 Q9Y2L1 EXOSC2 Homo sapiens Q13868 33961781
种属内
DIS3 Q9Y2L1 EXOSC2 Homo sapiens Q13868
TAP
20531386
种属内
DIS3 Q9Y2L1 EXOSC10 Homo sapiens Q01780 20531386
种属内
DIS3 Q9Y2L1 EXOSC10 Homo sapiens Q01780 21255825
种属内
DIS3 Q9Y2L1 EXOSC10 Homo sapiens Q01780 23756462
种属内
DIS3 Q9Y2L1 EXOSC3 Homo sapiens Q9NQT5 21255825
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia

Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]

Axenfeld-Rieger Syndrome, Type 2

Axenfeld-Rieger Syndrome Type 2

RIEG2

Rieger Syndrome, Type 2

Rieger Syndrome Type 2

Rieger Syndrome 2

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

PRLMNS

Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

Nephroblastoma

Fetal Macrosomia

Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance

Mgus

Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

Monoclonal Gammopathy Nos

Iga Gammopathy

Monoclonal Gammoglobulinopathy

Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa

Smoldering Myeloma
Blood Protein Disease

Blood Protein Disorders

Blood Protein Disorder

Colon Leiomyoma

Colonic Leiomyoma

Plasma Cell Leukemia

Plasma Cell Leukaemia

Leukemia, Plasma Cell

Plasmacytic Leukaemia

Plasmacytic Leukemia

Pcl

Plasma Cell Leukaemia, Nos

Leukemic Plasma Cell

Plasma Cell Leukaemia Without Mention Of Remission

Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330

Nodular Malignant Melanoma

Nodular Melanoma

Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia

Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DIS3 RGD RGD:1304646
Canis familiaris DIS3 VGNC VGNC:39962
Mus musculus DIS3 MGD MGI:1919912
Bos taurus DIS3 VGNC VGNC:28072
Felis catus DIS3 VGNC VGNC:61499
Macaca mulatta DIS3 VGNC VGNC:71687