2. Gene
  3. EXOSC7 - exosome component 7 Gene

EXOSC7 - exosome component 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外泌体组分 7

种属: Homo sapiens

同用名: p8; EAP1; RRP42; Rrp42p; hRrp42p

基因 ID: 23016 | 基因类型: protein coding

关于 EXOSC7

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:44,976,244-45,012,668 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 11.2), skin (RPKM 10.6) and 25 other tissues.

功能概要

预测具有 3'-5'-核糖核酸外切酶活性和 RNA 结合活性。预测参与 RNA 代谢过程。外泌体的一部分 (RNase 复合物) 。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable 3'-5'-exoribonuclease activity and RNA binding activity. Predicted to be involved in RNA metabolic process. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC7 基因产物(1)

mRNA Protein Name
NM_015004.4 NP_055819.2 exosome complex component RRP42
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables RNA exonuclease activity IDA
IDA: 通过直接分析推断
17174896 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11719186 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
17174896 GOA
involved in RNA processing IDA
IDA: 通过直接分析推断
17174896 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
20531386 GOA
part of exosome (RNase complex) IDA
IDA: 通过直接分析推断
20531389 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
20531386 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20531386 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EXOSC7 蛋白结构

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (32 - 166)

RNase_PH_C

RNase_PH_C: 3' exoribonuclease family, domain 2 (197 - 261)

  • 0
  • 100
  • 200
  • 291 a.a.
蛋白主名 其他名称

exosome complex component RRP42

exosome complex exonuclease RRP42

EXOSC7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
33961781
Intra EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
28514442
Intra EXOSC7 Q15024 EXOSC2 Homo sapiens Q13868
Y2H
12419256
Intra EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
21255825
Intra EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Y2H
15231747
Intra EXOSC7 Q15024 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
33961781
Intra EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Y2H
12419256
Intra EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Anti Tag CoIP
33961781
Intra EXOSC7 Q15024 EXOSC4 Homo sapiens Q9NPD3
Anti Tag CoIP
28514442
Intra EXOSC7 Q15024 EXOSC1 Homo sapiens Q9Y3B2
Y2H
12419256
Intra EXOSC7 Q15024 EXOSC1 Homo sapiens Q9Y3B2
Pull Down
11812149
Intra EXOSC7 Q15024 IP6K1 Homo sapiens Q92551
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Trichohepatoenteric Syndrome 2

THES2
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04603 EXOSC7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus EXOSC7 MGD MGI:1913696
Macaca mulatta EXOSC7 VGNC VGNC:72383
Canis familiaris EXOSC7 VGNC VGNC:40527
Rattus norvegicus EXOSC7 RGD RGD:1309758
Felis catus EXOSC7 VGNC VGNC:62009
Bos taurus EXOSC7 VGNC VGNC:28661
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z