2. Gene
  3. EXOSC4 - exosome component 4 Gene

EXOSC4 - exosome component 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：外泌体组分 4

种属: Homo sapiens

同用名: SKI6; p12A; RRP41; Ski6p; RRP41A; Rrp41p; hRrp41p

基因 ID: 54512 | 基因类型: protein coding

关于 EXOSC4

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,064,056-144,080,648 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 2 paralogues. Broad expression in testis (RPKM 19.8), kidney (RPKM 7.7) and 25 other tissues.

功能概要

启用 mRNA 3'-UTR AU 富集区结合活性。参与核酸代谢过程和细胞生长的正向调节。作用于对病毒的防御反应上游或内部。位于胞质溶胶中；核质；和转录活性染色质。外泌体的一部分 (RNase 复合物) 。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA 3'-UTR AU-rich region binding activity. Involved in nucleic acid metabolic process and positive regulation of cell growth. Acts upstream of or within defense response to virus. Located in cytosol; nucleoplasm; and transcriptionally active chromatin. Part of exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]

EXOSC4 基因产物(1)

mRNA Protein Name
NM_019037.3 NP_061910.1 exosome complex component RRP41
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables RNA exonuclease activity IDA
IDA: 通过直接分析推断
17174896 GOA
enables mRNA 3'-UTR AU-rich region binding IDA
IDA: 通过直接分析推断
16912217 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11719186 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA deamination IDA
IDA: 通过直接分析推断
21255825 GOA
involved in RNA catabolic process IDA
IDA: 通过直接分析推断
17174896 GOA
involved in RNA processing IDA
IDA: 通过直接分析推断
17174896 GOA
acts upstream of or within defense response to virus IMP
IMP: 通过突变表型推断
21791617 GOA
involved in histone mRNA catabolic process IMP
IMP: 通过突变表型推断
18172165 GOA
involved in maturation of 5.8S rRNA IMP
IMP: 通过突变表型推断
20368444 GOA
involved in nuclear mRNA surveillance IMP
IMP: 通过突变表型推断
17545563 GOA
involved in nuclear-transcribed mRNA catabolic process IMP
IMP: 通过突变表型推断
17545563 GOA
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
17545563 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17545563 GOA
located in cytosol IDA
IDA: 通过直接分析推断
20531386 GOA
located in euchromatin IMP
IMP: 通过突变表型推断
20699273 GOA
part of exosome (RNase complex) IDA
IDA: 通过直接分析推断
20531389 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
20531386 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17545563 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EXOSC4 蛋白结构

RNase_PH

RNase_PH: 3' exoribonuclease family, domain 1 (21 - 152)

RNase_PH_C

RNase_PH_C: 3' exoribonuclease family, domain 2 (155 - 219)

  • 0
  • 100
  • 200
  • 245 a.a.
蛋白主名 其他名称

exosome complex component RRP41

exosome complex exonuclease RRP41

EXOSC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra EXOSC4 Q9NPD3 EXOSC2 Homo sapiens Q13868
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
26496610
Intra EXOSC4 Q9NPD3 EXOSC2 Homo sapiens Q13868
Anti Tag CoIP
33961781
Intra EXOSC4 Q9NPD3 EXOSC2 Homo sapiens Q13868
Y2H
12419256
Intra EXOSC4 Q9NPD3 EXOSC2 Homo sapiens Q13868
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
Crosslink
30021884
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
Anti Tag CoIP
33961781
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
Anti Tag CoIP
26496610
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
Y2H
15231747
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC9 Homo sapiens Q06265
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
26496610
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
33961781
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
Y2H
15231747
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC10 Homo sapiens Q01780
Anti Tag CoIP
21255825
Intra EXOSC4 Q9NPD3 EXOSC7 Homo sapiens Q15024
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC7 Homo sapiens Q15024
Anti Tag CoIP
33961781
Intra EXOSC4 Q9NPD3 EXOSC7 Homo sapiens Q15024
Anti Tag CoIP
26496610
Intra EXOSC4 Q9NPD3 EXOSC7 Homo sapiens Q15024
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC7 Homo sapiens Q15024
MAPPIT
25416956
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
21255825
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
26496610
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
33961781
Intra EXOSC4 Q9NPD3 EXOSC3 Homo sapiens Q9NQT5
Y2H
15231747
Intra EXOSC4 Q9NPD3 EXOSC1 Homo sapiens Q9Y3B2
Anti Bait CoIP
20531386
Intra EXOSC4 Q9NPD3 EXOSC1 Homo sapiens Q9Y3B2
TAP
24981860
Intra EXOSC4 Q9NPD3 EXOSC1 Homo sapiens Q9Y3B2
Anti Tag CoIP
26496610
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Heel Spur

Calcaneal Spur
Lipodystrophy, Familial Partial, Type 3

FPLD3

Pparg-Related Familial Partial Lipodystrophy

Familial Partial Lipodystrophy Type 3

Familial Partial Lipodystrophy Associated With Pparg Mutations

Pparg-Related Fpld

Lipodystrophy, Familial Partial, Associated With Pparg Mutations

Insulin Resistance, Severe, Digenic

Lipodystrophy, Familial Partial, 3

Familial Partial Lipodystrophy, Type 3
Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia, Type 1c

PCH1C

Hypomyelination With Spinal Muscular Atrophy And Cerebellar Hypoplasia

Pontocerebellar Hypoplasia Type 1c

Pontocerebellar Hypoplasia 1c

Doid:0112334

Hypoplasia, Pontocerebellar, Type 1c
Trichohepatoenteric Syndrome 1

Trichohepatoenteric Syndrome

Syndromic Diarrhea

Tricho-Hepato-Enteric Syndrome

Sd/The

Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

THES1

Phenotypic Diarrhea

Thes

Phenotypic Diarrhea Of Infancy

Diarrhea, Syndromic

Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

Intractable Diarrhea With Phenotypic Anomalies

Syndromatic Diarrhea

Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04600 EXOSC4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus EXOSC4 VGNC VGNC:81652
Macaca mulatta EXOSC4 VGNC VGNC:72294
Bos taurus EXOSC4 VGNC VGNC:28659
Mus musculus EXOSC4 MGD MGI:1923576
Canis familiaris EXOSC4 VGNC VGNC:40525
Rattus norvegicus EXOSC4 RGD RGD:1310986
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