MBD3 - methyl-CpG binding domain protein 3 Gene

中文名称：甲基-CpG 结合域蛋白 3

种属: Homo sapiens

关于 MBD3

功能概要

DNA 甲基化是真核生物基因组的主要修饰，在哺乳动物发育中起着至关重要的作用。该基因属于核蛋白家族，其特征在于存在甲基-CpG 结合域 (MBD) 。编码的蛋白质是 NuRD 的一个亚基，NuRD 是一种多亚基复合物，包含核小体重塑和组蛋白脱乙酰酶活性。与其他家族成员不同，编码的蛋白质不能与甲基化 DNA 结合。该蛋白介导转移相关蛋白 2 与核心组蛋白脱乙酰酶复合物的结合。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 7 月]

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]